LY-2584702
|
|
|
- CAS号:
- 1082949-67-4
- 英文名:
- LY2584702
- 英文别名:
- CS-1752;LY2584702;LY2584702 BASE;LY2584702 TsOH;LY2584702 USP/EP/BP;LY-2584702 (free base);LY-2584702 free base
(LY2584702);4-[4-[4-[4-Fluoro-3-(trifluoromethyl)phenyl]-1-methylimidazol-2-yl]piperidin-1-yl]-1H-pyrazolo;4-[4-[4-[4-Fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl]-1-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidine;1H-Pyrazolo[3,4-d]pyrimidine, 4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl]-1-piperidinyl]-
- 中文名:
- LY-2584702
- 中文别名:
- 化合物LY-2584702;P70S6K信号转导抑制剂(LY-2584702 FREE BASE);4-(4-(4-(4-氟-3-(三氟甲基)苯基)-1-甲基-1H-咪唑-2-基)哌啶-1-基)-1H-吡唑并[3,4-D]嘧啶
- CBNumber:
- CB52728813
- 分子式:
- C21H19F4N7
- 分子量:
- 445.42
- MOL File:
- 1082949-67-4.mol
|
|
|
LY-2584702化学性质
-
储存条件:
-
RT (des.)
-
|
-
溶解度:
-
Soluble in DMSO (up to 1 mg/ml) or in DMF (up to 3 mg/ml).
-
|
-
形态:
-
solid
-
|
-
颜色:
-
Yellow
-
|
-
稳定性:
-
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months.
-
|
LY-2584702性质、用途与生产工艺
LY2584702是一种选择性的，ATP竞争性的p70S6K抑制剂，IC50为4 nM。Phase 1。
In HCT116 colon cancer cells, LY2584702 inhibits phosphorylation of the S6 ribosomal protein (pS6) with IC50 of 0.1-0.24 μM. LY2584702 has significant synergistic effects when combined with EGFR inhibitor erlotinib or with the mTOR inhibitor everolimus.
LY2584702 (12.5 mg/kg BID), demonstrates significant antitumor efficacy in both U87MG glioblastoma and HCT116 colon carcinoma xenograft models.
LY2584702是一种选择性的，ATP竞争性的p70S6K抑制剂，IC50为4 nM。Phase 1。
在HCT116结肠癌细胞，LY2584702抑制S6核糖体蛋白质(pS6)的磷酸化，IC50 为0.1-0.24 μM。 LY258470与EGRF抑制剂erlotinib或mTOR抑制剂everolimus结合时，具有显著的协同效应。
LY2584702 (12.5 mg/kg BID)，在U87MG 成胶质细胞瘤和HCT116结肠癌异种移植物模型中表现出显著的抗肿瘤作用。
LY-2584702
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | S7698 | LY-2584702
LY2584702 | 1082949-67-4 | 5mg | 1218.71元 |
| 2024/11/08 | S7698 | LY-2584702
LY2584702 | 1082949-67-4 | 25mg | 3647.46元 |
1082949-67-4, LY-2584702 相关搜索:
- Inhibitors
- 合成有机化合物配体
- 细胞生物学试剂
- 小分子抑制剂，天然产物
- 抑制剂
- C21H19F4N7
- 4-(4-(4-(4-氟-3-(三氟甲基)苯基)-1-甲基-1H-咪唑-2-基)哌啶-1-基)-1H-吡唑并[3,4-D]嘧啶
- 化合物LY-2584702
- P70S6K信号转导抑制剂(LY-2584702 FREE BASE)
- 1082949-67-4
- Ribosomal S6 Kinase (RSK),LY2584702,LY 2584702,S6K,Inhibitor,inhibit,LY2584702 free base,LY 2584702 free base,LY-2584702
- LY2584702 BASE
- LY-2584702 free base
(LY2584702)
- CS-1752
- 1H-Pyrazolo[3,4-d]pyrimidine, 4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl]-1-piperidinyl]-
- LY2584702 USP/EP/BP
- 4-[4-[4-[4-Fluoro-3-(trifluoromethyl)phenyl]-1-methylimidazol-2-yl]piperidin-1-yl]-1H-pyrazolo
- 4-[4-[4-[4-Fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl]-1-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidine
- 4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-imidazol-2-yl]-1-piperidyl]-1H-pyrazolo[3,4-d]pyrimidine LY2584702
- LY2584702 TsOH
- LY-2584702 (free base)
- LY2584702