2-甲基柠檬酸
|
|
|
- CAS号:
- 6061-96-7
- 英文名:
- 2-METHYLCITRIC ACID
- 英文别名:
- Methylcitric acid;2-METHYLCITRIC ACID;DL-2-METHYLCITRIC ACID;YNOXCRMFGMSKIJ-UHFFFAOYSA-N;2-Methylcitric Acid (unlabelled);2-hydroxybutane-1,2,3-tricarboxylic acid;1,2,3-Butanetricarboxylic acid, 2-hydroxy-;2-Hydroxy-3-methyl-1,2,3-propanetricarboxylic acid;2-Methylcitric Acid (mixture of diastereomers) (unlabelled)
- 中文名:
- 2-甲基柠檬酸
- 中文别名:
- 2-甲基柠檬酸;(±)-2-甲基柠檬酸[干冰运输]
- CBNumber:
- CB4308627
- 分子式:
- C7H10O7
- 分子量:
- 206.15
- MOL File:
- 6061-96-7.mol
|
|
|
2-甲基柠檬酸化学性质
-
熔点:
-
79 °C
-
|
-
沸点:
-
313.1±42.0 °C(Predicted)
-
|
-
密度:
-
1.637±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
Refrigerator
-
|
-
溶解度:
-
DMSO (Slightly), Methanol (Slightly)
-
|
-
形态:
-
Solid
-
|
-
酸度系数(pKa):
-
2.93±0.20(Predicted)
-
|
-
颜色:
-
White to Off-White
-
|
-
稳定性:
-
Hygroscopic
-
|
2-甲基柠檬酸性质、用途与生产工艺
2-Methylcitric acid (Methylcitric acid) 是 2- 甲基柠檬酸循环的内源性代谢物。2-Methylcitric acid 在甲基丙二酸血症和丙二酸酸血症中积累并能作为代谢标志物。2-Methylcitric acid 对谷氨酸支持的线粒体中 ADP 刺激和不耦合呼吸作用有明显的抑制作用。
|
Human Endogenous Metabolite
|
2-Methylcitric acid (Methylcitric acid) impairs glutamate metabolism and induces permeability transition in brain mitochondria. 2-Methylcitric acid inhibits glutamate dehydrogenase (GDH) activity at concentrations as low as 0.5 mM.
2-Methylcitric acid (1-3 mM; 150 seconds) provokes a significant decrease in mitochondrial membrane potential and induced swelling in Ca
2+
-loaded mitochondria supported by different substrates.
2-Methylcitric acid behaves as a potent inhibitor of glutamate oxidation by inhibiting glutamate dehydrogenase activity and as a permeability transition inducer, disturbing mitochondrial energy homeostasis. 2-Methylcitric acid does not significantly impair mitochondrial glutamate transport. 2-Methylcitric acid does not significantly impair glutamate mitochondrial transport in liver mitochondria.
2-甲基柠檬酸
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-113371 | 2-甲基柠檬酸
2-Methylcitric acid | 6061-96-7 | 5mg | 1400元 |
| 2024/04/30 | HY-113371 | 2-甲基柠檬酸
2-Methylcitric acid | 6061-96-7 | 10mg | 2400元 |
6061-96-7, 2-甲基柠檬酸 相关搜索:
- 高端化学
- 抑制剂
- 对照品
- HOOCCH2COHCOOHCHCH3COOH
- C7H10O7
- (±)-2-甲基柠檬酸[干冰运输]
- 2-甲基柠檬酸
- 6061-96-7
- 1,2,3-Butanetricarboxylic acid, 2-hydroxy-
- 2-Methylcitric Acid (mixture of diastereomers) (unlabelled)
- YNOXCRMFGMSKIJ-UHFFFAOYSA-N
- 2-METHYLCITRIC ACID
- Methylcitric acid
- 2-Hydroxy-3-methyl-1,2,3-propanetricarboxylic acid
- 2-hydroxybutane-1,2,3-tricarboxylic acid
- 2-Methylcitric Acid (unlabelled)
- DL-2-METHYLCITRIC ACID