2-甲基柠檬酸
| 中文名称 | 2-甲基柠檬酸 |
|---|---|
| 中文同义词 | 2-甲基柠檬酸;(±)-2-甲基柠檬酸[干冰运输];2-羟基丁烷-1,2,3-三羧酸 |
| 英文名称 | 2-METHYLCITRIC ACID |
| 英文同义词 | DL-2-METHYLCITRIC ACID;2-Methylcitric Acid (unlabelled);2-hydroxybutane-1,2,3-tricarboxylic acid;2-Hydroxy-3-methyl-1,2,3-propanetricarboxylic acid;Methylcitric acid;2-METHYLCITRIC ACID;YNOXCRMFGMSKIJ-UHFFFAOYSA-N;2-Methylcitric Acid (mixture of diastereomers) (unlabelled) |
| CAS号 | 6061-96-7 |
| 分子式 | C7H10O7 |
| 分子量 | 206.15 |
| EINECS号 | |
| 相关类别 | 对照品 |
| Mol文件 | 6061-96-7.mol |
| 结构式 |  |
2-甲基柠檬酸 性质
| 熔点 | 79 °C |
|---|---|
| 沸点 | 313.1±42.0 °C(Predicted) |
| 密度 | 1.637±0.06 g/cm3(Predicted) |
| 储存条件 | Refrigerator |
| 溶解度 | 可溶于DMSO（少许）、甲醇（少许） |
| 形态 | 固体 |
| 酸度系数(pKa) | 2.93±0.20(Predicted) |
| 颜色 | 白色至类白色 |
| 稳定性 | 吸湿性 |
|
Human Endogenous Metabolite
|
2-Methylcitric acid (Methylcitric acid) impairs glutamate metabolism and induces permeability transition in brain mitochondria. 2-Methylcitric acid inhibits glutamate dehydrogenase (GDH) activity at concentrations as low as 0.5 mM.
2-Methylcitric acid (1-3 mM; 150 seconds) provokes a significant decrease in mitochondrial membrane potential and induced swelling in Ca
2+
-loaded mitochondria supported by different substrates.
2-Methylcitric acid behaves as a potent inhibitor of glutamate oxidation by inhibiting glutamate dehydrogenase activity and as a permeability transition inducer, disturbing mitochondrial energy homeostasis. 2-Methylcitric acid does not significantly impair mitochondrial glutamate transport. 2-Methylcitric acid does not significantly impair glutamate mitochondrial transport in liver mitochondria.