Pifithrin-α, p-nitro, cyclic
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- CAS号:
- 60477-38-5
- 英文名:
- Pifithrin-α, p-nitro, cyclic
- 英文别名:
- PFN-α;p-Nitro-CyclicPifithrin-α;p-Nitro-Cyclic Pifithrin-a;Cyclic pifithrin-α-p-nitro;p-nitro-Cyclic Pifithrin-α;Cyclic pifithrin-α-p-nitro;Pifithrin-α, p-nitro, cyclic;Pifithrin-alpha, p-Nitro, Cyclic;p-nitro Cyclic Pifithrin-.alpha.;Pifithrin-α, p-Nitro, Cyclic - CAS 60477-38-5 - Calbiochem
- 中文名:
- Pifithrin-α, p-nitro, cyclic
- 中文别名:
- PIFITHRIN-Α (P53抑制剂);PIFITHRIN-Α, P-NITRO, CYCLIC;化合物PIFITHRIN-Α, P-NITRO, CYCLIC;5,6,7,8-四氢-2-(4-硝基苯基)咪唑并[2,1-b]苯并噻唑
- CBNumber:
- CB43136760
- 分子式:
- C15H13N3O2S
- 分子量:
- 299.35
- MOL File:
- 60477-38-5.mol
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Pifithrin-α, p-nitro, cyclic化学性质
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熔点:
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233-234 °C(Solv: N,N-dimethylformamide (68-12-2); water (7732-18-5))
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密度:
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1.53±0.1 g/cm3(Predicted)
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储存条件:
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-20C
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溶解度:
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≤1mg/ml in dimethyl formamide
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形态:
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Yellow solid
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酸度系数(pKa):
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6.14±0.20(Predicted)
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颜色:
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Light yellow to yellow
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Pifithrin-α, p-nitro, cyclic性质、用途与生产工艺
Pifithrin-α, p-Nitro, Cyclic (PFN-α)，是细胞通透性的 p53 抑制剂。Pifithrin-α, p-Nitro, Cyclic 对暴露于 Etoposide 的皮层神经元的保护作用比 Pifithrin-α 强一个数量级 (ED50=30 nM)。Pifithrin-α, p-Nitro, Cyclic 也作为 p53 转录后活性抑制剂。Pifithrin-α, p-Nitro, Cyclic 不阻止 p53 上的 S15 残基磷酸化。
Pifithrin-α, p-Nitro, Cyclic (PFN-α) efficiently blocks p53-triggered cell death and p21/WAF1 expression in cortical neurons exposed to etoposide at concentrations one order magnitude lower than that in PFT-α.
Intraocular injection of pifithrin-α slightly increases survival of retinal ganglion cell (RGC) at the concentration of 6 μM but not at 0.06 μM. Pifithrin-α, p-Nitro, Cyclic (PFN-α) is not effective in vivo, even at 6 μM.
Pifithrin-α, p-Nitro, Cyclic shows the half-life (t
1/2
) of 6 hours (when incubated in biological conditions).
Pifithrin-α, p-nitro, cyclic
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-123076 | Pifithrin-α, p-Nitro, Cyclic | | 1 mg | 454元 |
| 2024/08/19 | HY-123076 | Pifithrin-α, p-nitro, cyclic
Pifithrin-α, p-Nitro, Cyclic | 60477-38-5 | 5mg | 1000元 |
Pifithrin-α, p-nitro, cyclic
生产厂家
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