Pifithrin-α, p-nitro, cyclic 化学特性,用途語,生産方法
使用
p-nitro-Cyclic Pifithrin-α is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptisis. Anti-cancer agent.
一般的な説明
A cell-permeable p53 inhibitor that exhibits 10-fold higher potency (ED
50 = 30 nM in protecting etoposide-induced cortical neuron death) and 50% longer half-life (
t1/2 = 6h in neuron culture medium at 37°C) than Pifithrin-α (Cat. No.
506132). However, despite its
in vitro efficacy, this inhibitor is not effective when adminstered in rats
in vivo. For
in vivo applications, please consider Pifithrin-α,
p-Nitro (Cat. No.
506152).
Biochem/physiol Actions
Cell permeable: yes
Pifithrin-α, p-nitro, cyclic 上流と下流の製品情報
原材料
準備製品