N-乙酰基-S-法呢基-L-半胱氨酸
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- CAS号:
- 135304-07-3
- 英文名:
- AFC
- 英文别名:
- AFC;AFC USP/EP/BP;AC-CYS(FARNESYL)-OH;Ac-L-Cys(Farnesyl)-OH;AC-CYSTEINE(FARNESYL)-OH;N-Acetyl-L-farnesylcysteine;n-acetyl-s-farnesylcysteine;ACETYL-S-FARNESYL-L-CYSTEINE;N-ACETYL-S-FARNESYL-L-CYSTEINE;N-ALPHA-ACETYL-S-FARNESYL-L-CYSTEINE
- 中文名:
- N-乙酰基-S-法呢基-L-半胱氨酸
- 中文别名:
- 乙酰法尼基半胱氨酸;化合物 T10363;化合物 ARAZINE;N-乙酰基-L-法呢基半胱氨酸;N-乙酰基-S-法呢基-L-半胱氨酸;N-乙酰基-S-TRANS,TRANS-法尼基-L-半胱氨酸
- CBNumber:
- CB4379892
- 分子式:
- C20H33NO3S
- 分子量:
- 367.55
- MOL File:
- 135304-07-3.mol
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N-乙酰基-S-法呢基-L-半胱氨酸化学性质
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沸点:
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566.1±50.0 °C(Predicted)
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密度:
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1.038±0.06 g/cm3(Predicted)
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储存条件:
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-15°C
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溶解度:
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Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml)
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形态:
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Pale yellow oil.
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酸度系数(pKa):
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3.31±0.10(Predicted)
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颜色:
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Yellow
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稳定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
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LogP:
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5.860 (est)
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N-乙酰基-S-法呢基-L-半胱氨酸性质、用途与生产工艺
Arazine (N-Acetyl-S-farnesyl-L-cysteine) 是 G 蛋白和 G 蛋白偶联受体 (G protein and G-protein coupled receptor) 信号传导的细胞渗透性调节剂。Arazine 可与异戊烯化的 G 蛋白或其受体位点竞争，成为异戊二烯基半胱氨酸甲基转移酶的底物。
Arazine (2 hours) inhibits ATPγS induced CXCL1, CXCL8 and CCL2 production as a dose-dependent manner in HMEC-1 cell.
Arazine (10–100 μM;8 hours) significantly affects the HMEC-1 cell viability as measured by trypan blue exclusion in HMEC-1 cell.
Arazine (AFC) (2,000 μg/20 μl; applied on ear) produces a dose-dependent inhibition of the TPA-induced edema, with the maximal reduction of edema approaching 73%, with a 50% effective dose (ED
50
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Animal Model:
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TPA-induced ear acute inflammation in mouse
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Dosage:
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2000 μg/20 μl
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Administration:
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2000 μg/20 μl; Applied on ear
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Result:
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Inhibited ear edema, as measured by ear weight.
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N-乙酰基-S-法呢基-L-半胱氨酸
上下游产品信息
上游原料
下游产品
135304-07-3, N-乙酰基-S-法呢基-L-半胱氨酸 相关搜索:
- 抑制剂
- C20H33NO3S
- 163479-47-3
- 化合物 ARAZINE
- 化合物 T10363
- N-乙酰基-S-TRANS,TRANS-法尼基-L-半胱氨酸
- N-乙酰基-L-法呢基半胱氨酸
- 乙酰法尼基半胱氨酸
- N-乙酰基-S-法呢基-L-半胱氨酸
- 135304-07-3
- L-Cysteine,N-acetyl-S-(3,7,11-trimethyl-2,6,10-dodecatrienyl)-, (E,E)-
- AFC USP/EP/BP
- (R)-2-acetamido-3-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienylthio) propanoic acid
- L-Cysteine,N-acetyl-S-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]-
- N-Acetyl-S-(3,7,11-trimethyl-2ε,6ε,10-dodecatrienyl)-L-cysteine
- Ac-L-Cys(Farnesyl)-OH
- Acetyl-S-farnesyl-L-cysteine≥ 99% (TLC)
- N-Acetyl-S-trans,trans-farnesyl-L-cysteine
- N-Acetyl-L-farnesylcysteine
- N-Acetyl-S-farnesyl-L-cysteine (AFC)
- n-acetyl-s-farnesylcysteine
- N-ALPHA-ACETYL-S-FARNESYL-L-CYSTEINE
- N-ACETYL-S-FARNESYL-L-CYSTEINE
- N-ACETYL-S-(3,7,11-TRIMETHYL-2E,6E,10-DODECATRIENYL)-L-CYSTEINE
- ACETYL-S-FARNESYL-L-CYSTEINE
- AC-CYS(FARNESYL)-OH
- AC-CYSTEINE(FARNESYL)-OH
- AFC