SN 6
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- CAS号:
- 415697-08-4
- 英文名:
- 2-[[4-[(4-NITROPHENYL)METHOXY]PHENYL]METHYL]-4-THIAZOLIDINECARBOXYLIC ACID ETHYL ESTER
- 英文别名:
- SN-6;SN-6;SN6;SN 6;inhibit,SN 6,Na+/Ca2+ Exchanger,SN-6,Inhibitor;Ethyl 2-(4-((4-nitrobenzyl)oxy)benzyl)thiazolidine-4-carboxylate;2-[[4-[(4-NITROPHENYL)METHOXY]PHENYL]METHYL]-4-THIAZOLIDINECARBOXYLIC ACID ETHYL ESTER;4-Thiazolidinecarboxylic acid, 2-[[4-[(4-nitrophenyl)methoxy]phenyl]methyl]-, ethyl ester
- 中文名:
- SN 6
- 中文别名:
- 化合物SN6;SN6,NA + / CA2 +交换抑制剂(反向模式);2-(4-((4-硝基苄基)氧基)苄基)噻唑烷-4-羧酸乙酯
- CBNumber:
- CB4690807
- 分子式:
- C20H22N2O5S
- 分子量:
- 402.46
- MOL File:
- 415697-08-4.mol
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SN 6化学性质
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沸点:
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581.2±50.0 °C(Predicted)
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密度:
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1.285±0.06 g/cm3(Predicted)
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储存条件:
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Keep in dark place,Sealed in dry,2-8°C
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溶解度:
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DMSO : 62.5 mg/mL (155.29 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
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形态:
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Powder
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酸度系数(pKa):
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6.63±0.60(Predicted)
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颜色:
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White to light yellow
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SN 6性质、用途与生产工艺
SN-6 是一种选择性的 Na+/Ca2+ exchanger (NCX) 抑制剂。SN-6 可抑制NCX1、NCX2和NCX3，对应的IC50值分别为2.9 μM、16 μM和8.6 μM。SN-6 可消除 acetylcholine (ACh) 诱导的血管舒张。
| Target | Value |
NCX1
(Cell-free assay)
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2.9 μM
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NCX3
(Cell-free assay)
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8.6 μM
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NCX2
(Cell-free assay)
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16 μM
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SN 6 is a selective Na
+
/Ca
2+
exchanger inhibitor, which inhibits the initial rate of
45
Ca
2+
uptake into NCX1, NCX2, and NCX3 transfectants with IC
50
values of 2.9 ± 0.12, 16 ± 1.1, and 8.6 ± 0.27 μM. SN 6 (up to 30 μM) also less potently inhibits muscarinic acetylcholine receptor, with a higher IC
50
of 18 μM. SN 6 (0.3-30 μM) completely inhibits the initial rate of Na
+
i
-dependent
45
Ca
2+
uptake into Na
+
-loaded sarcolemmal vesicles in a dose dependent manner (IC
50
, 5.3 ± 0.37 μM). SN 6 (0.3-10 μM) dose-dependently protects against the hypoxia/reoxygenation-induced LDH release in parental LLC-PK1 cells and NCX1 transfectants but not in K229Q transfectants. SN 6 (1-30 μM) suppresses the bidirectional outward and inward I
NCX
in a concentration-dependent manner, with IC
50
values of 2.3 μM and 1.9 μM, respectively. SN 6 also inhibits bidirectional current (I
NCX
) in a [Na
+
]i concentration-dependent manner, with IC
50
values of 3.4 μM, 2.3 μM, and 1.1 μM at 10 mM, 20 mM, and 30 mM [Na
+
]i, respectively. SN 6 inhibits hypoxia/reoxygenation-induced LDH release with an IC
50
value of 0.63 ± 0.15 μM in NCX1 transfectants.
SN 6
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-107658 | SN 6
SN 6 | 415697-08-4 | 5mg | 840元 |
| 2024/04/30 | HY-107658 | SN 6
SN 6 | 415697-08-4 | 10mM * 1mLin DMSO | 924元 |
SN 6
生产厂家
全球有 68家供应商
SN 6国内生产厂家
415697-08-4, SN 6 相关搜索:
- Ion transporter and other ion channel
- 药靶配体
- SN6,NA + / CA2 +交换抑制剂(反向模式)
- 2-(4-((4-硝基苄基)氧基)苄基)噻唑烷-4-羧酸乙酯
- 化合物SN6
- 415697-08-4
- inhibit,SN 6,Na+/Ca2+ Exchanger,SN-6,Inhibitor
- Ethyl 2-(4-((4-nitrobenzyl)oxy)benzyl)thiazolidine-4-carboxylate
- 4-Thiazolidinecarboxylic acid, 2-[[4-[(4-nitrophenyl)methoxy]phenyl]methyl]-, ethyl ester
- SN-6;SN6;SN 6
- 2-[[4-[(4-NITROPHENYL)METHOXY]PHENYL]METHYL]-4-THIAZOLIDINECARBOXYLIC ACID ETHYL ESTER
- SN-6