磷酸氢化可的松
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- CAS号:
- 3863-59-0
- 英文名:
- 11beta,17,21-trihydroxypregn-4-ene-3,20-dione 21-(dihydrogen phosphate)
- 英文别名:
- Corphos;NSC 529660;Cortisol phosphate;Cortisol 21-phosphate;Hydrocortisone phosphate;Cortisol 21-monophosphate;Hydrocortisone 21-phosphate;Cortisol 21-phosphoric acid;21-Hydrocortisonephosphoric acid;Hydrocortisone dihydrogen phosphate
- 中文名:
- 磷酸氢化可的松
- 中文别名:
- 磷酸氢化可的松
- CBNumber:
- CB4900397
- 分子式:
- C21H31O8P
- 分子量:
- 442.44
- MOL File:
- 3863-59-0.mol
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磷酸氢化可的松化学性质
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沸点:
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669.9±65.0 °C(Predicted)
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密度:
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1.42±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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1.67±0.10(Predicted)
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磷酸氢化可的松性质、用途与生产工艺
磷酸氢化可的松 (Hydrocortisone 21-phosphate) 是一种糖皮质激素,是一种具有口服活性的甾体抗炎药 (SAID)。 Hydrocortisone phosphate 抑制 IL-6 和 IL-3 的生物活性,IC50 值分别为 6.7 和 21.4 μM。 磷酸氢化可的松可用于溃疡性结肠炎 (UC) 的研究。
磷酸氢化可的松作为一种糖皮质激素,抗炎作用为可的松的1.25倍,还具有免疫抑制作用、抗毒作用、抗休克等。临床可用于各种急性严重细菌感染、严重的过敏性疾病、红斑狼疮、湿疹等。
Hydrocortisone phosphate (Hydrocortisone 21-phosphate),一种糖皮质激素, 是口服活性的甾体抗炎剂 (SAID)。Hydrocortisone phosphate 抑制 IL-6 和 IL-3 的生物活性,IC50 值分别为 6.7 和 21.4 μM。Hydrocortisone phosphate 可用于溃疡性结肠炎 (UC) 的研究。
IL-6
6.7 μM (IC
50
)
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IL-3
21.4 μM (IC
50
)
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Hydrocortisone phosphate inhibits IL-6 and IL-3 bioactivity, with IC
50
s of 6.7 and 21.4 μM, respectively, and shows no cytotoxic effects on IL-6-independent MH60 cells.
Hydrocortisone phosphate (0.12-60 μM; 72 h) inhibits phytohemagglutinin (PHA) response in peripheral lymphocytes (PBL) and T-lymphocytes cultures.
Hydrocortisone phosphate (30 mg/kg; p.o. twice daily for 5 d) reduces the weight loss and increases the food intake in mice.
Animal Model:
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Male Sprague-Dawley rats (200-220 g, 10-11 weeks) are induced colitis
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Dosage:
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30 mg/kg
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Administration:
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P.o. twice daily for 5 days
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Result:
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Significantly decreased the disease activity index (DAI) scores and myeloperoxidase (MPO) activity compared to the 2, 4, 6-trinitrobenzenesulfonic acid (TNBS) group.
Increased the body weight.
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磷酸氢化可的松
上下游产品信息
上游原料
下游产品
3863-59-0, 磷酸氢化可的松 相关搜索:
- C21H31O8P
- 磷酸氢化可的松
- 3863-59-0
- Cortisol 21-phosphoric acid
- 11β,17α-Dihydroxy-21-(phosphonooxy)pregn-4-ene-3,20-dione
- 11β,17-Dihydroxy-21-(phosphonooxy)pregn-4-ene-3,20-dione
- Pregn-4-ene-3,20-dione, 11,17-dihydroxy-21-(phosphonooxy)-, (11β)-
- NSC 529660
- Hydrocortisone dihydrogen phosphate
- Hydrocortisone 21-phosphate
- Hydrocortisone 21-(dihydrogen phosphate)
- Cortisol, 21-(dihydrogen phosphate) (7CI, 8CI)
- Cortisol phosphate
- Cortisol 21-phosphate
- Cortisol 21-monophosphate
- Corticosterone, 17-hydroxy-, 21-phosphate (6CI)
- Corphos
- 21-Hydrocortisonephosphoric acid
- Hydrocortisone phosphate
- 11beta,17,21-trihydroxypregn-4-ene-3,20-dione 21-(dihydrogen phosphate)