磷酸氢化可的松
| 中文名称 | 磷酸氢化可的松 |
|---|---|
| 中文同义词 | 磷酸氢化可的松;氢化可的松磷酸盐 |
| 英文名称 | 11beta,17,21-trihydroxypregn-4-ene-3,20-dione 21-(dihydrogen phosphate) |
| 英文同义词 | 11beta,17,21-trihydroxypregn-4-ene-3,20-dione 21-(dihydrogen phosphate);Hydrocortisone phosphate;21-Hydrocortisonephosphoric acid;Corphos;Corticosterone, 17-hydroxy-, 21-phosphate (6CI);Cortisol 21-monophosphate;Cortisol 21-phosphate;Cortisol phosphate |
| CAS号 | 3863-59-0 |
| 分子式 | C21H31O8P |
| 分子量 | 442.44 |
| EINECS号 | 223-382-2 |
| 相关类别 | |
| Mol文件 | 3863-59-0.mol |
| 结构式 |  |
磷酸氢化可的松 性质
| 沸点 | 669.9±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.42±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 1.67±0.10(Predicted) |
磷酸氢化可的松 (Hydrocortisone 21-phosphate) 是一种糖皮质激素，是一种具有口服活性的甾体抗炎药 (SAID)。 Hydrocortisone phosphate 抑制 IL-6 和 IL-3 的生物活性，IC50 值分别为 6.7 和 21.4 μM。 磷酸氢化可的松可用于溃疡性结肠炎 (UC) 的研究。
磷酸氢化可的松作为一种糖皮质激素，抗炎作用为可的松的1.25倍，还具有免疫抑制作用、抗毒作用、抗休克等。临床可用于各种急性严重细菌感染、严重的过敏性疾病、红斑狼疮、湿疹等。
Hydrocortisone phosphate (Hydrocortisone 21-phosphate)，一种糖皮质激素， 是口服活性的甾体抗炎剂 (SAID)。Hydrocortisone phosphate 抑制 IL-6 和 IL-3 的生物活性，IC50 值分别为 6.7 和 21.4 μM。Hydrocortisone phosphate 可用于溃疡性结肠炎 (UC) 的研究。|
IL-6 6.7 μM (IC 50 ) |
IL-3 21.4 μM (IC 50 ) |
Hydrocortisone phosphate inhibits IL-6 and IL-3 bioactivity, with IC
50
s of 6.7 and 21.4 μM, respectively, and shows no cytotoxic effects on IL-6-independent MH60 cells.
Hydrocortisone phosphate (0.12-60 μM; 72 h) inhibits phytohemagglutinin (PHA) response in peripheral lymphocytes (PBL) and T-lymphocytes cultures.
Hydrocortisone phosphate (30 mg/kg; p.o. twice daily for 5 d) reduces the weight loss and increases the food intake in mice.
| Animal Model: | Male Sprague-Dawley rats (200-220 g, 10-11 weeks) are induced colitis |
| Dosage: | 30 mg/kg |
| Administration: | P.o. twice daily for 5 days |
| Result: |
Significantly decreased the disease activity index (DAI) scores and myeloperoxidase (MPO) activity compared to the 2, 4, 6-trinitrobenzenesulfonic acid (TNBS) group.
Increased the body weight. |