氟舒胺
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- CAS号:
- 80937-31-1
- 英文名:
- Flosulide
- 英文别名:
- ZK-38997;CGP-28328;CGP-28238;Flosulide;N-[1-Oxo-6-(2,4-difluorophenoxy)indan-5-yl]methanesulfonamide;N-[[6-(2,4-Difluorophenoxy)-2,3-dihydro-1-oxo-1H-inden]-5-yl]methanesulfonamide;Methanesulfonamide, N-[6-(2,4-difluorophenoxy)-2,3-dihydro-1-oxo-1H-inden-5-yl]-
- 中文名:
- 氟舒胺
- 中文别名:
- 氟舒胺;化合物 T11296;化合物 FLOSULIDE
- CBNumber:
- CB51178758
- 分子式:
- C16H13F2NO4S
- 分子量:
- 353.344
- MOL File:
- 80937-31-1.mol
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氟舒胺化学性质
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熔点:
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156 °C(Solv: ethanol (64-17-5))
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沸点:
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446.9±55.0 °C(Predicted)
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密度:
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1.506±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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6.95±0.20(Predicted)
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氟舒胺性质、用途与生产工艺
Flosulide 是一种有效的，选择性的 COX-2 抑制剂，常用于炎症研究。
Flosulide (1 nM-100 μM) causes a concentration-dependent and finally complete inhibition of PGE2 production in the OSC-2 cell line, but with no effect on PG formation in the OSC-1 cells. Flosulide completely suppresses mitotic activity of OSC-2 cells, whereas mitotic activity of OSC-1 cells remain unchanged.
In normovolemic rats, flosulide increases renal plasma flow (RPF) and and glomerular filtration rate (GFR). In hypovolemic rats, flosulide (5-25 mg/kg) reduces RPF and GFR. Flosulide at 5 mg/kg reduces 6-keto-PGF1alpha whereas at 25 mg/kg and after indomethacin at 10 mg/kg a fall in 6-keto-PGF1alpha and TXB2 appeares. Flosulide (0.75 mg/day) significantly reduces proteinuria as compared to aspirin treatment. Plasma protein and albumin levels are significantly lower in the aspirin-treated group than in flosulide-treated rats.
氟舒胺
上下游产品信息
上游原料
下游产品
80937-31-1, 氟舒胺 相关搜索:
- 抑制剂
- 化合物 FLOSULIDE
- 化合物 T11296
- 氟舒胺
- 80937-31-1
- Methanesulfonamide, N-[6-(2,4-difluorophenoxy)-2,3-dihydro-1-oxo-1H-inden-5-yl]-
- ZK-38997
- N-[1-Oxo-6-(2,4-difluorophenoxy)indan-5-yl]methanesulfonamide
- Flosulide
- N-[[6-(2,4-Difluorophenoxy)-2,3-dihydro-1-oxo-1H-inden]-5-yl]methanesulfonamide
- CGP-28328
- CGP-28238