8-(4-氨基苯基)-2-(4-吗啉基)-4H-1-苯并吡喃-4-酮
|
|
|
- CAS号:
- 942289-87-4
- 英文名:
- PI 828
- 英文别名:
- PI 828;PI 828,PI828;LY 294002, 4′-NH2;LY 294002, 4-NH - CAS 942289-87-4 - Calbiochem;8-(4-aminophenyl)-2-morpholin-4-ylchromen-4-one;8-(4-Aminophenyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one;2-(4-Morpholinyl)-8-(4-aminopheny)l-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 8-(4-aminophenyl)-2-(4-morpholinyl)-
- 中文名:
- 8-(4-氨基苯基)-2-(4-吗啉基)-4H-1-苯并吡喃-4-酮
- 中文别名:
- 化合物 T16528;8-(4-氨基苯基)-2-(4-吗啉基)-4H-1-苯并吡喃-4-酮
- CBNumber:
- CB52455753
- 分子式:
- C19H18N2O3
- 分子量:
- 322.36
- MOL File:
- 942289-87-4.mol
|
|
|
8-(4-氨基苯基)-2-(4-吗啉基)-4H-1-苯并吡喃-4-酮化学性质
-
沸点:
-
534.2±50.0 °C(Predicted)
-
|
-
密度:
-
1.316±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
Store at +4°C
-
|
-
溶解度:
-
DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: slightly soluble
-
|
-
酸度系数(pKa):
-
4.14±0.10(Predicted)
-
|
-
形态:
-
Off-white solid
-
|
-
颜色:
-
White to yellow
-
|
8-(4-氨基苯基)-2-(4-吗啉基)-4H-1-苯并吡喃-4-酮性质、用途与生产工艺
PI-828 是一种双重 PI3K 和 casein kinase 2 (CK2) 抑制剂，抑制 p110α，CK2 和 CK2α2，IC50 分别为 173 nM，149 nM 和 1127 nM。
|
p110α
173 nM (IC
50
)
|
CK2
149 nM (IC
50
)
|
CK2α2
1.127 μM (IC
50
)
|
PI-828 (0.01-100 μM) exhibits cytotoxic effect on the 4T1 breast cancer cells and 4306 ovarian cancer cells.
PI-828 (0.78-3.12 µM; 48 hours) decreases caspase 3 activation; higher concentrations of PI-828 (6.25-12.5 μM) alone causes apoptosis.
Cell Viability Assay
|
Cell Line:
|
4T1 breast cancer cells and 4306 ovarian cancer cells
|
|
Concentration:
|
0.01, 0.1, 1, 10 and 100 μM
|
|
Incubation Time:
|
|
|
Result:
|
Exhibited cytotoxic effect.
|
Apoptosis Analysis
|
Cell Line:
|
Human embryonic carcinoma NCCIT cells
|
|
Concentration:
|
0.78, 1.56, 3.12, 6.25, 12.5 μM
|
|
Incubation Time:
|
48 hours
|
|
Result:
|
Concentrations of ranging from 0.78 to 3.12 µM decreased caspase 3 activation; higher concentrations caused apoptosis.
|
8-(4-氨基苯基)-2-(4-吗啉基)-4H-1-苯并吡喃-4-酮
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-108606 | PI-828 | | 1 mg | 1590元 |
| 2024/04/30 | HY-108606 | PI-828 | | 10 mM * 1 mLin DMSO | 2482元 |
8-(4-氨基苯基)-2-(4-吗啉基)-4H-1-苯并吡喃-4-酮
生产厂家
942289-87-4, 8-(4-氨基苯基)-2-(4-吗啉基)-4H-1-苯并吡喃-4-酮 相关搜索:
- 药靶配体
- 化合物 T16528
- 8-(4-氨基苯基)-2-(4-吗啉基)-4H-1-苯并吡喃-4-酮
- 942289-87-4
- 4H-1-Benzopyran-4-one, 8-(4-aminophenyl)-2-(4-morpholinyl)-
- PI 828,PI828
- LY 294002, 4′-NH2
- LY 294002, 4-NH - CAS 942289-87-4 - Calbiochem
- 8-(4-aminophenyl)-2-morpholin-4-ylchromen-4-one
- 8-(4-Aminophenyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one
- 2-(4-Morpholinyl)-8-(4-aminopheny)l-4H-1-benzopyran-4-one
- PI 828