硫丙咪胺
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- CAS号:
- 106243-16-7
- 英文名:
- THIOPERAMIDE MALEATE
- 英文别名:
- Thiop;MR 12842;thioperamide;THIOPERAMIDE MALEATE;THIOPERAMIDE MALEATE SALT;THIOPERAMIDE MALEATE (MR 12842) POTENT A ND SELECTIVE;N-Cyclohexyl-4-(imidazol-4-yl)-1-piperidinecarbothioamide;N-Cyclohexyl-4-(1H-imidazol-4-yl)-1-piperidinecarbothioamide;N-CYCLOHEXYL-4-(1H-IMIDAZOL-5-YL)-1-PIPERIDINECARBOTHIOAMIDE;N-Cyclohexyl-4-(1H-imidazol-5-yl)piperidine-1-carbothioamide
- 中文名:
- 硫丙咪胺
- 中文别名:
- 硫丙咪胺;化合物 T23456;化合物 THIOPERAMIDE;N-环己基-4-(1H-咪唑-5-基)哌啶-1-硫代氨基
- CBNumber:
- CB5245732
- 分子式:
- C15H24N4S
- 分子量:
- 292.44
- MOL File:
- 106243-16-7.mol
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硫丙咪胺化学性质
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储存条件:
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Store at -20°C
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溶解度:
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H2O: 10 mg/mL
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形态:
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solid
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颜色:
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white
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硫丙咪胺性质、用途与生产工艺
Thioperamide (MR-12842) 是一种有效的，具有口服活性的，可透过血脑屏障的选择性 H3 受体拮抗剂，抑制 [3H] 组胺释放的 Ki 为 4.3 nM。Thioperamide 抑制 [3H] 组胺合成的 Ki 为 31 nM 。
Thioperamide inhibits [
3
H]-(R)α-MeHA binding rat brain and guinea-pig lung with K
i
s of 2.1 nM and 2.0 nM, respectively. Thioperamide competitively blocks H3-autoreceptors regulating [
3
H]histamine release with a mean apparent K
i
of 4 nM.
Thioperamide (0.01-100 μM; 24 hours) promotes the viability of NE-4C stem cells in a concentration-dependent manner.
Cell Viability Assay
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Cell Line:
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NE-4C stem cells
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Concentration:
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0.01, 0.1, 1, 10, 100 μM
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Incubation Time:
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24 hours
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Result:
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The viability of NE-4C stem cells increased significantly to 150.83±6.91% when (1 μM) was administrated, and increased to 145.11±14.52% and 132.02%±25.65% when 10 μM and 100 μM were administrated respectively.
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Thioperamide (5-20 mg/kg; i.p.) is able to facilitate reconsolidation of a contextually-conditioned fear memory in C57BL/6J mice.
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Animal Model:
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Naive female C57BL/6J mice
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Dosage:
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5, 10 or 20 mg/kg
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Administration:
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Injections (i.p.)
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Result:
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Facilitated reconsolidation of a contextually-conditioned fear memory.
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硫丙咪胺
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | HY-12206A | Thioperamide maleate | | 5 mg | 1000元 |
| 2024/11/08 | HY-12206A | Thioperamide maleate | | 10 mg | 1600元 |
硫丙咪胺
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硫丙咪胺国内生产厂家
106243-16-7, 硫丙咪胺 相关搜索:
- Histamine
- Histamine receptor
- 抑制剂
- Potent and selective H3 histamine receptor antagonist that crosses the blood-brain barrier.
- C15H24N4SC4H4O4
- 化合物 THIOPERAMIDE
- N-环己基-4-(1H-咪唑-5-基)哌啶-1-硫代氨基
- 化合物 T23456
- 硫丙咪胺
- 106243-16-7
- 1-Piperidinecarbothioamide, N-cyclohexyl-4-(1H-imidazol-5-yl)-
- N-Cyclohexyl-4-(1H-imidazol-5-yl)piperidine-1-carbothioamide
- N-CYCLOHEXYL-4-(1H-IMIDAZOL-5-YL)-1-PIPERIDINECARBOTHIOAMIDE
- N-CYCLOHEXYL-4-(IMIDAZOL-4-YL)-1-PIPERIDINECARBOTHIOAMIDE MALEATE
- thioperamide
- N-Cyclohexyl-4-(imidazol-4-yl)-1-piperidinecarbothioamide
- Thiop
- N-Cyclohexyl-4-(1H-imidazol-4-yl)-1-piperidinecarbothioamide
- THIOPERAMIDE MALEATE (MR 12842) POTENT A ND SELECTIVE
- THIOPERAMIDE MALEATE SALT
- THIOPERAMIDE MALEATE
- MR 12842
- N-CYCLOHEXYL-4-(1H-IMIDAZOL-4-YL)-1-PIPERIDINECARBOTHIOAMIDE MALEATE