硫丙咪胺
| 中文名称 | 硫丙咪胺 |
|---|---|
| 中文同义词 | 硫丙咪胺;化合物 T23456;N-环己基-4-(1H-咪唑-5-基)哌啶-1-硫代氨基;化合物 THIOPERAMIDE |
| 英文名称 | THIOPERAMIDE MALEATE |
| 英文同义词 | N-CYCLOHEXYL-4-(1H-IMIDAZOL-4-YL)-1-PIPERIDINECARBOTHIOAMIDE MALEATE;MR 12842;THIOPERAMIDE MALEATE;THIOPERAMIDE MALEATE SALT;THIOPERAMIDE MALEATE (MR 12842) POTENT A ND SELECTIVE;N-Cyclohexyl-4-(1H-imidazol-4-yl)-1-piperidinecarbothioamide;Thiop;N-Cyclohexyl-4-(imidazol-4-yl)-1-piperidinecarbothioamide |
| CAS号 | 106243-16-7 |
| 分子式 | C15H24N4S |
| 分子量 | 292.44 |
| EINECS号 | |
| 相关类别 | Histamine receptor;Histamine |
| Mol文件 | 106243-16-7.mol |
| 结构式 |  |
硫丙咪胺 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 在水中的溶解度10 mg/mL |
| 形态 | 固体 |
| 颜色 | 白色 |
Thioperamide (MR-12842) 是一种有效的，具有口服活性的，可透过血脑屏障的选择性 H3 受体拮抗剂，抑制 [3H] 组胺释放的 Ki 为 4.3 nM。Thioperamide 抑制 [3H] 组胺合成的 Ki 为 31 nM 。
|
H 3 Receptor
|
Thioperamide inhibits [
3
H]-(R)α-MeHA binding rat brain and guinea-pig lung with K
i
s of 2.1 nM and 2.0 nM, respectively. Thioperamide competitively blocks H3-autoreceptors regulating [
3
H]histamine release with a mean apparent K
i
of 4 nM.
Thioperamide (0.01-100 μM; 24 hours) promotes the viability of NE-4C stem cells in a concentration-dependent manner.
Cell Viability Assay
| Cell Line: | NE-4C stem cells |
| Concentration: | 0.01, 0.1, 1, 10, 100 μM |
| Incubation Time: | 24 hours |
| Result: | The viability of NE-4C stem cells increased significantly to 150.83±6.91% when (1 μM) was administrated, and increased to 145.11±14.52% and 132.02%±25.65% when 10 μM and 100 μM were administrated respectively. |
Thioperamide (5-20 mg/kg; i.p.) is able to facilitate reconsolidation of a contextually-conditioned fear memory in C57BL/6J mice.
| Animal Model: | Naive female C57BL/6J mice |
| Dosage: | 5, 10 or 20 mg/kg |
| Administration: | Injections (i.p.) |
| Result: | Facilitated reconsolidation of a contextually-conditioned fear memory. |
| 提供商 | 语言 |
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英文
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