网站主页 >> CAS数据库列表 >> 2-[(1R)-1-[[(4-氯苯基)磺酰基](2,5-二氟苯基)氨基]乙基]-5-氟苯丁酸
2-[(1R)-1-[[(4-氯苯基)磺酰基](2,5-二氟苯基)氨基]乙基]-5-氟苯丁酸
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- CAS号:
- 290315-45-6
- 英文名:
- 2-[(1R)-1-[[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl]-5-fluoroBenzenebutanoic acid
- 英文别名:
- BMS 299897;BMS-299897
(BMS 299897;γ-Secretase Inhibitor XXIV, BMS299897;γ-Secretase Inhibitor XXIV, BMS299897 - CAS 290315-45-6 - Calbiochem;2-[(1R)-1-[[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl]-5-fluoroBenzenebutanoic acid;Benzenebutanoic acid, 2-[(1R)-1-[[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl]-5-fluoro-
- 中文名:
- 2-[(1R)-1-[[(4-氯苯基)磺酰基](2,5-二氟苯基)氨基]乙基]-5-氟苯丁酸
- 中文别名:
- 化合物 T14673;化合物 BMS 299897;2-[(1R)-1-[[(4-氯苯基)磺酰基](2,5-二氟苯基)氨基]乙基]-5-氟苯丁酸
- CBNumber:
- CB52473755
- 分子式:
- C24H21ClF3NO4S
- 分子量:
- 511.94
- MOL File:
- 290315-45-6.mol
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2-[(1R)-1-[[(4-氯苯基)磺酰基](2,5-二氟苯基)氨基]乙基]-5-氟苯丁酸化学性质
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沸点:
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620.0±65.0 °C(Predicted)
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密度:
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1.421±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: ≥20mg/mL
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酸度系数(pKa):
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4.71±0.10(Predicted)
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形态:
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White solid
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颜色:
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white to beige
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2-[(1R)-1-[[(4-氯苯基)磺酰基](2,5-二氟苯基)氨基]乙基]-5-氟苯丁酸性质、用途与生产工艺
BMS 299897 是一种磺胺类γ-secretase 抑制剂,作用于稳定过表达淀粉样前体蛋白 (APP) 的HEK293 细胞,抑制Aβ产生,IC50 为 7 nM。
IC50: 7 nM (Aβ, in HEK293 cells)
BMS-299897 reduces the levels of each of the Aβ peptides. At 1 μM, BMS-299897 decreases these peptides to levels ranging from 20 to 50% of the vehicle control. BMS-299897 treatment reduces the portion of QD-BDNF signals moving in the retrograde direction (p=0.0198) with a concomitant increase in the portion of signals moving in the anterograde direction (p=0.0147).
BMS-299897 shows dose- and time-dependent reductions of amyloid β-peptide (Aβ) in brain, cerebrospinal fluid (CSF), and plasma in young transgenic mice, with a correlation between brain and CSF Aβ levels. BMS-299897 reduces both brain and plasma Aβ
1-40
in APP-YAC mice and increases brain concentrations of APPcarboxy-terminal fragments, consistent with γ-secretase inhibition. BMS-299897, attenuates this Aβ
25-35
-induced Aβ
1-42
seeding and toxicity. BMS-299897 is administered at 0.1-1 nmol/mouse, concomittantly with Aβ
25-35
(9 nmol) in male Swiss mice. After one week, the contents in Aβ
1-42
and Aβ
1-40
, and the levels in lipid peroxidation are analyzed in the mouse hippocampus. Mice are submitted to spontaneous alternation, passive avoidance and object recognition to analyze their short- and long-term memory abilities. Aβ
25-35
increases Aβ
1-42
content (+240%) but fails to affect Aβ
1-40
. BMS-299897 blocks the increase in Aβ
1-42
content and decreased Aβ
1-40
levels significantly. The compound does not affect Aβ
25-35
-induced increase in hippocampal lipid peroxidation. Behaviorally, BMS-299897 blocks the Aβ
25-35
-induced deficits in spontaneous alternation or novel object recognition, using a 1 h intertrial time interval. The co-administration of the γ-secretase inhibitor BMS-299897, in the 0.1-1 μmol/mouse dose-range, completely blocks the Aβ
25-35
-induced increase in Aβ
1-42
content.
用途
BMS 299897 is a known γ-secretase inhibitor that effectively reduces amyloid β-peptide (Aβ) in transgenic mice and guinea pigs. Studies have shown the possibility of using BMS 299897 in the treatments
for Alzheimer鈥檚 patients.
2-[(1R)-1-[[(4-氯苯基)磺酰基](2,5-二氟苯基)氨基]乙基]-5-氟苯丁酸
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-50883 | 2-[(1R)-1-[[(4-氯苯基)磺酰基](2,5-二氟苯基)氨基]乙基]-5-氟苯丁酸 BMS 299897 | 290315-45-6 | 5mg | 850元 |
2024/08/19 | HY-50883 | 2-[(1R)-1-[[(4-氯苯基)磺酰基](2,5-二氟苯基)氨基]乙基]-5-氟苯丁酸 BMS 299897 | 290315-45-6 | 10mM * 1mLin DMSO | 957元 |
2-[(1R)-1-[[(4-氯苯基)磺酰基](2,5-二氟苯基)氨基]乙基]-5-氟苯丁酸
生产厂家
290315-45-6, 2-[(1R)-1-[[(4-氯苯基)磺酰基](2,5-二氟苯基)氨基]乙基]-5-氟苯丁酸 相关搜索:
- 药靶配体
- 抑制剂
- C24H21ClF3NO4S
- 化合物 BMS 299897
- 化合物 T14673
- 2-[(1R)-1-[[(4-氯苯基)磺酰基](2,5-二氟苯基)氨基]乙基]-5-氟苯丁酸
- 290315-45-6
- Benzenebutanoic acid, 2-[(1R)-1-[[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl]-5-fluoro-
- γ-Secretase Inhibitor XXIV, BMS299897 - CAS 290315-45-6 - Calbiochem
- BMS-299897
(BMS 299897
- γ-Secretase Inhibitor XXIV, BMS299897
- BMS 299897
- 2-[(1R)-1-[[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl]-5-fluoroBenzenebutanoic acid