HEMOPRESSIN (HUMAN, BOVINE, PORCINE)
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- CAS号:
- 1314035-51-2
- 英文名:
- Hemopressin (human, bovine, porcine)
- 英文别名:
- Hemopressin (human, bovine, porcine);H-Pro-Val-Asn-Phe-Lys-Leu-Leu-Ser-His-OH;L-Histidine, L-prolyl-L-valyl-L-asparaginyl-L-phenylalanyl-L-lysyl-L-leucyl-L-leucyl-L-seryl-
- 中文名:
- HEMOPRESSIN (HUMAN, BOVINE, PORCINE)
- 中文别名:
- 选择性CB1受体逆激动剂多肽PVNFKLLSH
- CBNumber:
- CB52476877
- 分子式:
- C50H79N13O12
- 分子量:
- 1054.24
- MOL File:
- 1314035-51-2.mol
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HEMOPRESSIN (HUMAN, BOVINE, PORCINE)化学性质
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沸点:
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1491.3±65.0 °C(Predicted)
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密度:
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1.258±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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酸度系数(pKa):
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2.77±0.10(Predicted)
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形态:
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Powder
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颜色:
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White to off-white
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水溶解性:
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Soluble to 1 mg/ml in water
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序列:
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H-Pro-Val-Asn-Phe-Lys-Leu-Leu-Ser-His-OH
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HEMOPRESSIN (HUMAN, BOVINE, PORCINE)性质、用途与生产工艺
Hemopressin 是一种源自血红蛋白 α1 链的九肽，最初是从大鼠脑匀浆中分离出来的。Hemopressin 是口服有效的，选择性的 CB1 大麻素受体的反向激动剂。Hemopressin 在炎性疼痛模型中发挥抗伤害感受作用。
Hemopressin causes hypotension in anesthetized rats and is metabolized in vivo and in vitro by endopeptidase 24.15 (EP24.15), neurolysin (EP24.16), and angiotensin-converting enzyme (ACE).
Oral administration of Hemopressin inhibits mechanical hyperalgesia of CCI-rats up to 6h. Hemopressin treatment also decreases Egr-1 immunoreactivity (Egr-1Ir) in the superficial layer of the dorsal horn of the spinal cord of CCI rats.
多肽
HEMOPRESSIN (HUMAN, BOVINE, PORCINE)作为一种选择性CB1受体逆激动剂多肽，序列中含有9个氨基酸，在体内显示出抗伤害感受的活性。
参考质量标准
外观:白色粉末
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
HEMOPRESSIN (HUMAN, BOVINE, PORCINE)
上下游产品信息
上游原料
下游产品
HEMOPRESSIN (HUMAN, BOVINE, PORCINE)
生产厂家
1314035-51-2, HEMOPRESSIN (HUMAN, BOVINE, PORCINE) 相关搜索:
- 药靶配体
- 多肽
- 目录肽
- 目录多肽
- 选择性CB1受体逆激动剂多肽PVNFKLLSH
- 1314035-51-2
- L-Histidine, L-prolyl-L-valyl-L-asparaginyl-L-phenylalanyl-L-lysyl-L-leucyl-L-leucyl-L-seryl-
- H-Pro-Val-Asn-Phe-Lys-Leu-Leu-Ser-His-OH
- Hemopressin (human, bovine, porcine)