DPP 728
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- CAS号:
- 207556-62-5
- 英文名:
- DPP 728
- 英文别名:
- DPP 728;6-[2-[[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino]ethylamino]pyridine-3-carbonitrile:dihydrochloride
- 中文名:
- 中文别名:
- CBNumber:
- CB52627781
- 分子式:
- C15H20Cl2N6O
- 分子量:
- 371.2649
- MOL File:
- 207556-62-5.mol
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DPP 728性质、用途与生产工艺
NVP-DPP728 dihydrochloride 是一种高效、选择性的二肽基肽酶 IV (DPP-IV) 抑制剂，其 Ki 为 11 nM。NVP-DPP728 dihydrochloride 可用于糖尿病的研究。
NVPDPP728 inhibits human and rat plasma DPP-IV (IC
50
s: 5-10 nM) with >15 000-fold selectivity relative to DPP-II and a range of proline-cleaving proteases.
NVP-DPP728 (3.72 mg/kg; p.o.) inhibits DPP-IV and improves insulin secretion and glucose tolerance, probably through augmentation of the effects of endogenous GLP-1.
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Animal Model:
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Obese (fa/fa) and lean (FA/?) Zucker rats
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Dosage:
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3.72 mg/kg
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Administration:
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Oral administration
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Result:
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Led to inhibition of plasma DPP-IV activity.
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DPP 728
上下游产品信息
上游原料
下游产品
207556-62-5, DPP 728 相关搜索:
- 207556-62-5
- 6-[2-[[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino]ethylamino]pyridine-3-carbonitrile:dihydrochloride
- DPP 728