| 中文名称 | DPP 728 |
|---|---|
| 中文同义词 | |
| 英文名称 | DPP 728 |
| 英文同义词 | DPP 728;6-[2-[[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino]ethylamino]pyridine-3-carbonitrile:dihydrochloride |
| CAS号 | 207556-62-5 |
| 分子式 | C15H20Cl2N6O |
| 分子量 | 371.2649 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 207556-62-5.mol |
| 结构式 |  |
DPP 728 性质
NVP-DPP728 dihydrochloride 是一种高效、选择性的二肽基肽酶 IV (DPP-IV) 抑制剂，其 Ki 为 11 nM。NVP-DPP728 dihydrochloride 可用于糖尿病的研究。
Ki: 11 nM (DPP-IV)
NVPDPP728 inhibits human and rat plasma DPP-IV (IC
50
s: 5-10 nM) with >15 000-fold selectivity relative to DPP-II and a range of proline-cleaving proteases.
NVP-DPP728 (3.72 mg/kg; p.o.) inhibits DPP-IV and improves insulin secretion and glucose tolerance, probably through augmentation of the effects of endogenous GLP-1.
| Animal Model: | Obese (fa/fa) and lean (FA/?) Zucker rats |
| Dosage: | 3.72 mg/kg |
| Administration: | Oral administration |
| Result: | Led to inhibition of plasma DPP-IV activity. |