YS-49 (Monohydrate)
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- CAS号:
- 132836-42-1
- 英文名:
- YS-49 (Monohydrate)
- 英文别名:
- YS-49 (Monohydrate)
- 中文名:
- YS-49 (Monohydrate)
- 中文别名:
- CBNumber:
- CB52682027
- 分子式:
- C??H??BrNO?
- 分子量:
- 0
- MOL File:
- 132836-42-1.mol
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YS-49 (Monohydrate)化学性质
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形态:
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Solid
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颜色:
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Off-white to gray
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YS-49 (Monohydrate)性质、用途与生产工艺
YS-49 (monohydrate) 是 PI3K/Akt (RhoA 的下游靶标) 的激活剂，可减少 3-甲基胆碱处理的细胞中 RhoA/PTEN 的激活。YS-49 能通过诱导血红素加氧酶 (HO-1) 来抑制血管紧张素 II (Ang II) 刺激 VSMC 细胞的增殖。YS-49 是异喹啉化合物生物碱，因能激活心脏 β-adrenoceptors 而具有强烈的正性肌力作用。
YS-49 (1-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) concentration-dependently inhibits the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to lipopolysaccharide (LPS) plus INF-γ, with
IC
50
values of 22 μM and 30 μM, respectively.
YS-49 (10-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) suppresses iNOS gene expression induced by LPS and/or cytokines in RAVSMC and RAW 264.7 cells at the transcriptional level.
Cell Viability Assay
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Cell Line:
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RAVSMC and RAW 264.7 cells
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Concentration:
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10 μΜ, 30 μΜ and 100 μΜ(RAVSMC); 1 μΜ, 10 μΜ and 100 μM (RAW 264.7)
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Incubation Time:
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18 hours
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Result:
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Inhibited the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to LPS+INF-γ, with
IC
50
values of 22 and 30 μM, respectively.
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Western Blot Analysis
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Cell Line:
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RAVSMC and RAW 264.7 cells
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Concentration:
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10 μΜ, 30 μΜ and 100 μΜ
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Incubation Time:
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18 hours
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Result:
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Concentration-dependently inhibited the expression of iNOS protein induced by LPS plus IFN-γ.
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YS-49 (5 mg/kg; intraperitoneal injection; 8 hours; male Sprague Dawley rats) treatment significantly reduces serum NOx levels in LPS-treated rats, the NOx levels reduce from 86 μM to 34 μM.
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Animal Model:
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Male Sprague Dawley rats (250-300 g)
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Dosage:
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5 mg/kg
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Administration:
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Intraperitoneal injection; 8 hours
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Result:
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Serum NOx levels were significantly reduced.
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YS-49 (Monohydrate)
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-15477A | YS-49 monohydrate | | 5 mg | 767元 |
| 2024/04/30 | HY-15477A | YS-49 (Monohydrate)
YS-49 monohydrate | 132836-42-1 | 10mg | 1228元 |
132836-42-1, YS-49 (Monohydrate) 相关搜索:
- 132836-42-1 (ANHYDROUS)
- YS-49 (Monohydrate)