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YS-49 (Monohydrate)

YS-49 (Monohydrate), 132836-42-1, 结构式
YS-49 (Monohydrate)
CAS号:
132836-42-1
英文名:
YS-49 (Monohydrate)
英文别名:
YS-49 (Monohydrate)
中文名:
YS-49 (Monohydrate)
中文别名:
CBNumber:
CB52682027
分子式:
C??H??BrNO?
分子量:
0
MOL File:
132836-42-1.mol

YS-49 (Monohydrate)化学性质

形态:
Solid
颜色:
Off-white to gray
安全信息

YS-49 (Monohydrate)性质、用途与生产工艺

生物活性

YS-49 (monohydrate) 是 PI3K/Akt (RhoA 的下游靶标) 的激活剂,可减少 3-甲基胆碱处理的细胞中 RhoA/PTEN 的激活。YS-49 能通过诱导血红素加氧酶 (HO-1) 来抑制血管紧张素 II (Ang II) 刺激 VSMC 细胞的增殖。YS-49 是异喹啉化合物生物碱,因能激活心脏 β-adrenoceptors 而具有强烈的正性肌力作用。

靶点

PI3K/Akt

体外研究

YS-49 (1-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) concentration-dependently inhibits the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to lipopolysaccharide (LPS) plus INF-γ, with IC 50 values of 22 μM and 30 μM, respectively.
YS-49 (10-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) suppresses iNOS gene expression induced by LPS and/or cytokines in RAVSMC and RAW 264.7 cells at the transcriptional level.

Cell Viability Assay

Cell Line: RAVSMC and RAW 264.7 cells
Concentration: 10 μΜ, 30 μΜ and 100 μΜ(RAVSMC); 1 μΜ, 10 μΜ and 100 μM (RAW 264.7)
Incubation Time: 18 hours
Result: Inhibited the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to LPS+INF-γ, with IC 50 values of 22 and 30 μM, respectively.

Western Blot Analysis

Cell Line: RAVSMC and RAW 264.7 cells
Concentration: 10 μΜ, 30 μΜ and 100 μΜ
Incubation Time: 18 hours
Result: Concentration-dependently inhibited the expression of iNOS protein induced by LPS plus IFN-γ.

体内研究

YS-49 (5 mg/kg; intraperitoneal injection; 8 hours; male Sprague Dawley rats) treatment significantly reduces serum NOx levels in LPS-treated rats, the NOx levels reduce from 86 μM to 34 μM.

Animal Model: Male Sprague Dawley rats (250-300 g)
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; 8 hours
Result: Serum NOx levels were significantly reduced.

YS-49 (Monohydrate) 上下游产品信息

上游原料

下游产品

YS-49 (Monohydrate) 试剂级价格

更新日期产品编号产品名称CAS编号包装价格
2024/04/30HY-15477AYS-49 monohydrate5 mg767元
2024/04/30HY-15477AYS-49 (Monohydrate)
YS-49 monohydrate
132836-42-110mg1228元

YS-49 (Monohydrate) 生产厂家

全球有 8家供应商   YS-49 (Monohydrate)国内生产厂家
供应商联系电话电子邮件国家产品数优势度
上海皓元医药股份有限公司 021-58950125 info@chemexpress.com 中国 7553 61
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn 美国 4863 58
广州市齐云生物技术有限公司 020-61288194 61288195 505721671@qq.com 中国 3868 58
Musechem +1-800-259-7612 info@musechem.com 美国 4662 60
爱必信(上海)生物科技有限公司 021-38015121 15000105423 chenjw@absin.cn 中国 24734 58
天津普西唐生物医药科技有限公司 010-60605840 15801484223 psaitong@jm-bio.com 中国 29778 58
 

132836-42-1, YS-49 (Monohydrate) 相关搜索:

  • 132836-42-1 (ANHYDROUS)
  • YS-49 (Monohydrate)
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