YS-49 (Monohydrate)
| 中文名称 | YS-49 (Monohydrate) |
|---|---|
| 中文同义词 | |
| 英文名称 | YS-49 (Monohydrate) |
| 英文同义词 | YS-49 (Monohydrate) |
| CAS号 | 132836-42-1 |
| 分子式 | C??H??BrNO? |
| 分子量 | 0 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 132836-42-1.mol |
| 结构式 |  |
YS-49 (Monohydrate) 性质
| 形态 | 固体 |
|---|---|
| 颜色 | 米白色至灰色 |
PI3K/Akt
YS-49 (1-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) concentration-dependently inhibits the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to lipopolysaccharide (LPS) plus INF-γ, with
IC
50
values of 22 μM and 30 μM, respectively.
YS-49 (10-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) suppresses iNOS gene expression induced by LPS and/or cytokines in RAVSMC and RAW 264.7 cells at the transcriptional level.
Cell Viability Assay
| Cell Line: | RAVSMC and RAW 264.7 cells |
| Concentration: | 10 μΜ, 30 μΜ and 100 μΜ(RAVSMC); 1 μΜ, 10 μΜ and 100 μM (RAW 264.7) |
| Incubation Time: | 18 hours |
| Result: | Inhibited the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to LPS+INF-γ, with IC 50 values of 22 and 30 μM, respectively. |
Western Blot Analysis
| Cell Line: | RAVSMC and RAW 264.7 cells |
| Concentration: | 10 μΜ, 30 μΜ and 100 μΜ |
| Incubation Time: | 18 hours |
| Result: | Concentration-dependently inhibited the expression of iNOS protein induced by LPS plus IFN-γ. |
YS-49 (5 mg/kg; intraperitoneal injection; 8 hours; male Sprague Dawley rats) treatment significantly reduces serum NOx levels in LPS-treated rats, the NOx levels reduce from 86 μM to 34 μM.
| Animal Model: | Male Sprague Dawley rats (250-300 g) |
| Dosage: | 5 mg/kg |
| Administration: | Intraperitoneal injection; 8 hours |
| Result: | Serum NOx levels were significantly reduced. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-15477A | YS-49 monohydrate | 5 mg | 767元 | |
| 2024/04/30 | HY-15477A | YS-49 (Monohydrate) YS-49 monohydrate | 132836-42-1 | 10mg | 1228元 |