CS-1305
|
|
|
- CAS号:
- 932730-51-3
- 英文名:
- CDDO-EA
- 英文别名:
- TP319;TP 319;RTA405;TP-319);CDDO-EA;RTA 405;RTA-405;CS-1305;CDDO ethyl amide;Bardoxolone ethyl amide
- 中文名:
- CS-1305
- 中文别名:
- 化合物CDDO-EA;化合物 T10733;NF-E2相关因子2/抗氧化反应元件(NRF2/ARE)激活剂(CDDO-EA)
- CBNumber:
- CB52705078
- 分子式:
- C33H46N2O3
- 分子量:
- 518.73
- MOL File:
- 932730-51-3.mol
|
|
|
CS-1305化学性质
-
沸点:
-
670.7±55.0 °C(Predicted)
-
|
-
密度:
-
1.13±0.1 g/cm3(Predicted)
-
|
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
DMSO: ≥ 34 mg/mL (65.54 mM)
-
|
-
形态:
-
Powder
-
|
-
酸度系数(pKa):
-
16.21±0.70(Predicted)
-
|
-
颜色:
-
White to off-white
-
|
CS-1305性质、用途与生产工艺
CDDO-EA 是一种 NF-E2 相关因子 2 /抗氧化反应元件 (Nrf2/ARE) 激活剂。
CDDO-EA potently activates Nrf2/ARE in a cell culture model of ALS and in the G93A SOD1 mouse model of ALS. CDDO-EA is a potent inducer of apoptosis in A549 lung cancer cells, as shown both by PARP cleavage and Annexin staining. CDDO-EA is more potent than CDDO itself as inducers of heme oxygenase-1 (HO-1). In RAW264.7 macrophage-like cells, CDDO-EA is 7-fold more potent than CDDO as suppressors of the ability of IFN-γ to induce iNOS.
The survival analysis shows that G93A mice treated with CDDO-EA, compared to G93A littermate controls, lives significantly longer. CDDO-EA treatment increases the life-span by 20.6 days from 124.05±3.7 days to 144.72±8.1 days (16.6%) (p<0.001). In CDDO-EA-treated G93A mice, the age of death is 141.4±5.2 days and the duration from the age of onset to the age of death is 57.6±7.6 days, which means that the age of death from onset is prolonged by 17.5 days (43%).
CS-1305
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-12213 | CDDO-EA | | 1 mg | 990元 |
| 2024/04/30 | HY-12213 | CS-1305
CDDO-EA | 932730-51-3 | 5mg | 2600元 |
932730-51-3, CS-1305 相关搜索:
- 抑制剂
- 细胞生物学试剂
- 化合物CDDO-EA
- 化合物 T10733
- NF-E2相关因子2/抗氧化反应元件(NRF2/ARE)激活剂(CDDO-EA)
- 932730-51-3
- Oleana-1,9(11)-dien-28-amide, 2-cyano-N-ethyl-3,12-dioxo-
- CS-1305
- CDDO EA, RTA 405, tP 319
- TP-319)
- TP319
- TP 319
- RTA-405
- RTA405
- RTA 405
- CDDO-EA
(CDDO ethyl amide
- CDDO ETHYL AMIDE;RTA405;TP319;RTA 405;TP 319;RTA-405;TP-319
- CDDO ethyl amide
- Bardoxolone ethyl amide
- CDDO-EA