CS-1305
| 中文名称 | CS-1305 |
|---|---|
| 中文同义词 | NF-E2相关因子2/抗氧化反应元件(NRF2/ARE)激活剂(CDDO-EA);化合物 T10733;化合物CDDO-EA |
| 英文名称 | CDDO-EA |
| 英文同义词 | CDDO-EA;Bardoxolone ethyl amide;CDDO ethyl amide;CDDO ETHYL AMIDE;RTA405;TP319;RTA 405;TP 319;RTA-405;TP-319;CDDO-EA (CDDO ethyl amide;RTA 405;RTA405;RTA-405 |
| CAS号 | 932730-51-3 |
| 分子式 | C33H46N2O3 |
| 分子量 | 518.73 |
| EINECS号 | |
| 相关类别 | 细胞生物学试剂 |
| Mol文件 | 932730-51-3.mol |
| 结构式 |  |
CS-1305 性质
| 沸点 | 670.7±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.13±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：≥34mg/mL（65.54mM） |
| 形态 | 粉末 |
| 酸度系数(pKa) | 16.21±0.70(Predicted) |
| 颜色 | 白色至米白色 |
Nrf2/ARE
CDDO-EA potently activates Nrf2/ARE in a cell culture model of ALS and in the G93A SOD1 mouse model of ALS. CDDO-EA is a potent inducer of apoptosis in A549 lung cancer cells, as shown both by PARP cleavage and Annexin staining. CDDO-EA is more potent than CDDO itself as inducers of heme oxygenase-1 (HO-1). In RAW264.7 macrophage-like cells, CDDO-EA is 7-fold more potent than CDDO as suppressors of the ability of IFN-γ to induce iNOS.
The survival analysis shows that G93A mice treated with CDDO-EA, compared to G93A littermate controls, lives significantly longer. CDDO-EA treatment increases the life-span by 20.6 days from 124.05±3.7 days to 144.72±8.1 days (16.6%) (p<0.001). In CDDO-EA-treated G93A mice, the age of death is 141.4±5.2 days and the duration from the age of onset to the age of death is 57.6±7.6 days, which means that the age of death from onset is prolonged by 17.5 days (43%).
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-12213 | CDDO-EA | 1 mg | 990元 | |
| 2024/04/30 | HY-12213 | CS-1305 CDDO-EA | 932730-51-3 | 5mg | 2600元 |