Company Name: |
Haoyuan Chemexpress Co., Ltd.
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Tel: |
021-58950125 |
Email: |
info@chemexpress.com |
Products Intro: |
Product Name:CDDO-EA CAS:932730-51-3 Purity:>98% Package:1293RMB/2mg
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| CDDO-EA Basic information |
Product Name: | CDDO-EA | Synonyms: | CDDO-EA;Bardoxolone ethyl amide;CDDO ethyl amide;CDDO ETHYL AMIDE;RTA405;TP319;RTA 405;TP 319;RTA-405;TP-319;CDDO-EA
(CDDO ethyl amide;RTA 405;RTA405;RTA-405 | CAS: | 932730-51-3 | MF: | C33H46N2O3 | MW: | 518.73 | EINECS: | | Product Categories: | | Mol File: | 932730-51-3.mol | ![CDDO-EA Structure](CAS/20200515/GIF/932730-51-3.gif) |
| CDDO-EA Chemical Properties |
Boiling point | 670.7±55.0 °C(Predicted) | density | 1.13±0.1 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | DMSO: ≥ 34 mg/mL (65.54 mM) | form | Powder | pka | 16.21±0.70(Predicted) | color | White to off-white |
| CDDO-EA Usage And Synthesis |
Biological Activity | CDDO-EA is a NF-E2-related factor 2/antioxidant response element (Nrf2/ARE) activator. | in vitro | CDDO-EA potently activates Nrf2/ARE in a cell culture model of ALS and in the G93A SOD1 mouse model of ALS. CDDO-EA is a potent inducer of apoptosis in A549 lung cancer cells, as shown both by PARP cleavage and Annexin staining. It is more potent than CDDO itself as inducers of heme oxygenase-1 (HO-1). In RAW264.7 macrophage-like cells, CDDO-EA is 7-fold more potent than CDDO as suppressors of the ability of IFN-γ to induce iNOS. | in vivo | The survival analysis shows that G93A mice treated with CDDO-EA, compared to G93A littermate controls, lives significantly longer. CDDO-EA treatment increases the life-span by 20.6 days from 124.05±3.7 days to 144.72±8.1 days (16.6%) (p<0.001). In CDDO-EA-treated G93A mice, the age of death is 141.4±5.2 days and the duration from the age of onset to the age of death is 57.6±7.6 days, which means that the age of death from onset is prolonged by 17.5 days (43%). | target | |
| CDDO-EA Preparation Products And Raw materials |
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