TCS 401
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- CAS号:
- 243966-09-8
- 英文名:
- TCS 401
- 英文别名:
- TCS 401 HCl;TCS-401;TCS401;TCS-401 Hydrochloride;TCS-401,inhibit,TCS 401,Inhibitor,TCS401,Phosphatase;2-(Carboxyformamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid hydrochloride
- 中文名:
- TCS 401
- 中文别名:
- 化合物TCS 401;TCS 401盐酸盐;TCS 401,PTP1B的抑制剂;2-(羧基甲酰胺基)-4,5,6,7-四氢噻吩并[2,3-C]吡啶-3-羧酸盐酸盐
- CBNumber:
- CB52716366
- 分子式:
- C10H11ClN2O5S
- 分子量:
- 306.72
- MOL File:
- 243966-09-8.mol
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TCS 401化学性质
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储存条件:
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under inert gas (nitrogen or Argon) at 2-8°C
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溶解度:
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0.1 M NaOH: 5 mg/ml
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形态:
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A crystalline solid
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颜色:
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Light yellow to khaki
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TCS 401性质、用途与生产工艺
TCS 401 是选择性的蛋白酪氨酸磷酸酶 1B (protein tyrosine phosphatase 1B) 抑制剂。
TCS-401 (0.5, 1, 2 μM) significantly increases the proliferation of RPE cells. TCS-401 significantly increases the expression of cyclin A and cyclin D1 at the concentrations of 1 and 2 μM in a concentration-dependent manner. TCS-401 at concentrations of 0.5, 1, and 2 μM significantly increases phosphorylation of Erk and Akt compared to the control group. The activation of Erk and Akt by TCS-401 is blocked by pretreatment with PD98059 and LY294002, respectively. CS-401 treatment activates the MEK/Erk and PI3K/Akt signaling pathways and induces proliferation, differentiation, and migration in RPE cells. CS-401 dose dependently inhibits the RPTC-Sup-induced reduction of fibronectin and α-SMA. At 1 μM, TCS-401 reverses the levels of fibronectin and α-SMA about onefold and at a dose of 2 μM, TCS-401 brings back fibronectin and α-SMA expression to near normal levels.
TCS 401
上下游产品信息
上游原料
下游产品
243966-09-8, TCS 401 相关搜索:
- 酶
- TCS 401,PTP1B的抑制剂
- 化合物TCS 401
- 2-(羧基甲酰胺基)-4,5,6,7-四氢噻吩并[2,3-C]吡啶-3-羧酸盐酸盐
- TCS 401盐酸盐
- 243966-09-8
- 2-(Carboxyformamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid hydrochloride
- TCS-401,inhibit,TCS 401,Inhibitor,TCS401,Phosphatase
- TCS-401 Hydrochloride
- TCS 401 HCl
- TCS-401;TCS401