TCS 401
| 中文名称 | TCS 401 |
|---|---|
| 中文同义词 | TCS 401盐酸盐;2-(羧基甲酰胺基)-4,5,6,7-四氢噻吩并[2,3-C]吡啶-3-羧酸盐酸盐;化合物TCS 401;TCS 401,PTP1B的抑制剂 |
| 英文名称 | TCS 401 |
| 英文同义词 | TCS-401;TCS401;TCS 401 HCl;TCS-401 Hydrochloride;TCS-401,inhibit,TCS 401,Inhibitor,TCS401,Phosphatase;2-(Carboxyformamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid hydrochloride |
| CAS号 | 243966-09-8 |
| 分子式 | C10H11ClN2O5S |
| 分子量 | 306.72 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 243966-09-8.mol |
| 结构式 |  |
TCS 401 性质
| 储存条件 | under inert gas (nitrogen or Argon) at 2-8°C |
|---|---|
| 溶解度 | 0.1 M NaOH：5 mg/mL |
| 形态 | 结晶固体 |
| 颜色 | 浅黄至卡其色 |
TCS-401 (0.5, 1, 2 μM) significantly increases the proliferation of RPE cells. TCS-401 significantly increases the expression of cyclin A and cyclin D1 at the concentrations of 1 and 2 μM in a concentration-dependent manner. TCS-401 at concentrations of 0.5, 1, and 2 μM significantly increases phosphorylation of Erk and Akt compared to the control group. The activation of Erk and Akt by TCS-401 is blocked by pretreatment with PD98059 and LY294002, respectively. CS-401 treatment activates the MEK/Erk and PI3K/Akt signaling pathways and induces proliferation, differentiation, and migration in RPE cells. CS-401 dose dependently inhibits the RPTC-Sup-induced reduction of fibronectin and α-SMA. At 1 μM, TCS-401 reverses the levels of fibronectin and α-SMA about onefold and at a dose of 2 μM, TCS-401 brings back fibronectin and α-SMA expression to near normal levels.