二丁酰环磷腺苷钙
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- CAS号:
- 938448-87-4
- 英文名:
- Bucladesine (calciuM salt)
- 英文别名:
- DC2797 calcium salt;Bucladesine (calciuM salt);Dibutyryl-cAMP calcium salt;Bucladesine calcium (DC2797);Bucladesine (calciuM salt),Bucladesinecalciumsalt
- 中文名:
- 二丁酰环磷腺苷钙
- 中文别名:
- 布拉地新钙盐;二丁酰环磷腺苷钙;BUCLADESINE钙盐;化合物 BUCLADESINE CALCIUM
- CBNumber:
- CB52735512
- 分子式:
- C18H26CaN5O8P
- 分子量:
- 511.48
- MOL File:
- 938448-87-4.mol
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二丁酰环磷腺苷钙化学性质
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储存条件:
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Store at -20°C
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溶解度:
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Water: 100 mg/mL (204.74 mM); DMSO: ≥ 100 mg/mL (204.74 mM)
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形态:
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Solid
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颜色:
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White to off-white
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二丁酰环磷腺苷钙性质、用途与生产工艺
Bucladesine calcium salt (Dibutyryl-cAMP calcium salt;DC2797 calcium salt) 是可渗透细胞的 cAMP 类似物,可通过增加细胞内 cAMP 水平,选择性激活 cAMP 依赖性蛋白激酶(PKA)。Bucladesine calcium salt 也有磷酸二酯酶 (PDE) 抑制剂的作用。
Bucladesine (bilateral infusion of 10 mM or 100 mM) leads to a significant reduction in escape latency and travel distance (showing an improvement in spatial memory) compared to the control, as assesed by Morris water maze task in male rats. Bucladesine at 1 mM and 5 mM concentrations infused within minutes after 0.5 mg nicotine infusion improves spatial memory retention in male rats.
Bucladesine (10 mM/side) combined with Nicotine (0.5 mM/side) results in a significant increase in the ChAT and VAChT immunoreactivity in CA1 regions, and increase in the optical density and amount of ChAT and VAChT immunostaining correlates with the decrease in escape latency and traveled distance in rats treated with Nicotine and low dose of Bucladesine.
Bucladesine is absorbed very rapidly and almost completely when the aqueous solution is applied to the site where the skin has been excised. Bucladesine is absorbed rapidly but slower than in the full-thickness abrasion rat model in the case of stripped skin.
Bucladesine (single or multiple administration of an emulsion containing 1.5%) is capable of significantly reducing the inflammatory oedema in the arachidonic acid induced ear oedema model in mice.
二丁酰环磷腺苷钙
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938448-87-4, 二丁酰环磷腺苷钙 相关搜索:
- 抑制剂
- 化学试剂
- C18H24N5O8P12Ca
- BUCLADESINE钙盐
- 化合物 BUCLADESINE CALCIUM
- 二丁酰环磷腺苷钙
- 布拉地新钙盐
- 938448-87-4
- Bucladesine (calciuM salt),Bucladesinecalciumsalt
- Bucladesine calcium (DC2797)
- Dibutyryl-cAMP calcium salt
- DC2797 calcium salt
- Bucladesine (calciuM salt)