二丁酰环磷腺苷钙
中文名称 | 二丁酰环磷腺苷钙 |
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中文同义词 | 布拉地新钙盐;二丁酰环磷腺苷钙;化合物 BUCLADESINE CALCIUM;BUCLADESINE钙盐 |
英文名称 | Bucladesine (calciuM salt) |
英文同义词 | Bucladesine (calciuM salt);DC2797 calcium salt;Dibutyryl-cAMP calcium salt;Bucladesine calcium (DC2797);Bucladesine (calciuM salt),Bucladesinecalciumsalt |
CAS号 | 938448-87-4 |
分子式 | C18H26CaN5O8P |
分子量 | 511.48 |
EINECS号 | |
相关类别 | |
Mol文件 | 938448-87-4.mol |
结构式 | ![]() |
二丁酰环磷腺苷钙 性质
储存条件 | Store at -20°C |
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溶解度 | 水:100mg/mL(204.74mM);二甲基亚砜:≥100mg/mL(204.74mM) |
形态 | 固体 |
颜色 | 白色至米白色 |
PKA
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PDE
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Bucladesine (bilateral infusion of 10 mM or 100 mM) leads to a significant reduction in escape latency and travel distance (showing an improvement in spatial memory) compared to the control, as assesed by Morris water maze task in male rats. Bucladesine at 1 mM and 5 mM concentrations infused within minutes after 0.5 mg nicotine infusion improves spatial memory retention in male rats.
Bucladesine (10 mM/side) combined with Nicotine (0.5 mM/side) results in a significant increase in the ChAT and VAChT immunoreactivity in CA1 regions, and increase in the optical density and amount of ChAT and VAChT immunostaining correlates with the decrease in escape latency and traveled distance in rats treated with Nicotine and low dose of Bucladesine.
Bucladesine is absorbed very rapidly and almost completely when the aqueous solution is applied to the site where the skin has been excised. Bucladesine is absorbed rapidly but slower than in the full-thickness abrasion rat model in the case of stripped skin.
Bucladesine (single or multiple administration of an emulsion containing 1.5%) is capable of significantly reducing the inflammatory oedema in the arachidonic acid induced ear oedema model in mice.