1361504-77-9
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- CAS号:
- 1361504-77-9
- 英文名:
- DG172 (dihydrochloride)
- 英文别名:
- DG-172;DG172 2HCl;DG-172 (hydrochloride);DG172 (dihydrochloride);(Z)-2-(2-Bromophenyl)-3-(4-(4-methylpiperazin-1-yl)phenyl)acrylonitrile dihydrochloride;(αZ)-2-Bromo-α-[[4-(4-methyl-1-piperazinyl)phenyl]methylene]benzeneacetonitriledihydrochloride;(αZ)-2-Bromo-α-[[4-(4-methyl-1-piperazinyl)phenyl]methylene]benzeneacetonitrile dihydrochloride;DG-172,DG172,DG172 dihydrochloride,PPAR,inhibit,DG 172,Inhibitor,Peroxisome proliferator-activated receptors
- 中文名:
- 1361504-77-9
- 中文别名:
- DG 172 2HCL,PPARΒ/Δ反向激动剂;化合物DG172 (DIHYDROCHLORIDE);(Z)-2-(2-溴苯基)-3-(4-(4-甲基哌嗪-1-基)苯基)丙烯腈二盐酸盐
- CBNumber:
- CB53122342
- 分子式:
- C20H21BrClN3
- 分子量:
- 418.76
- MOL File:
- 1361504-77-9.mol
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1361504-77-9化学性质
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储存条件:
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Store at -20°C
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溶解度:
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≤20mg/ml in ethanol;25mg/ml in DMSO;25mg/ml in dimethyl formamide
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形态:
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crystalline solid
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颜色:
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Light yellow to yellow
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1361504-77-9性质、用途与生产工艺
DG172 dihydrochloride 是一种选择性的 PPARβ/δ 拮抗剂，IC50 值为 27 nM。
DG172 dihydrochloride is a selective PPARβ/δ antagonist, with an IC
50
of 27 nM. DG172 enhances transcriptional corepressor recruitment, and down-regulates transcription of the PPARβ/δ target gene Angptl4 in mouse myoblasts (IC
50
, 9.5 nM). DG172 (1 µM) promotes the differentiation of dendritic cells (DCs) from GM-CSF-induced mouse bone marrow cells (BMCs) and reduces Ly6b
+
/Gr1
+
granulocytic cells. DG172 has effects on the transcriptome of GM-CSF differentiated BMCs from WT and Ppard null mice, and acts at a specific stage of GM-CSF-induced differentiation. DG172 (0.1, 1.0 µM) dose-dependently promotes proliferation of TM4 cells. DG172 reduces expression of claudin-11 in TM4 cells.
1361504-77-9
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-19737A | 1361504-77-9
DG172 dihydrochloride | 1361504-77-9 | 5mg | 700元 |
| 2024/08/19 | HY-19737A | 1361504-77-9
DG172 dihydrochloride | 1361504-77-9 | 10mM * 1mLin Water | 770元 |
1361504-77-9, 1361504-77-9 相关搜索:
- 抑制剂
- 药靶配体
- C20H20BrN32HCl
- DG 172 2HCL,PPARΒ/Δ反向激动剂
- (Z)-2-(2-溴苯基)-3-(4-(4-甲基哌嗪-1-基)苯基)丙烯腈二盐酸盐
- 化合物DG172 (DIHYDROCHLORIDE)
- 1361504-77-9
- (αZ)-2-Bromo-α-[[4-(4-methyl-1-piperazinyl)phenyl]methylene]benzeneacetonitriledihydrochloride
- DG-172,DG172,DG172 dihydrochloride,PPAR,inhibit,DG 172,Inhibitor,Peroxisome proliferator-activated receptors
- (Z)-2-(2-Bromophenyl)-3-(4-(4-methylpiperazin-1-yl)phenyl)acrylonitrile dihydrochloride
- (αZ)-2-Bromo-α-[[4-(4-methyl-1-piperazinyl)phenyl]methylene]benzeneacetonitrile dihydrochloride
- DG-172
- DG172 2HCl
- DG-172 (hydrochloride)
- DG172 (dihydrochloride)