DG172 (dihydrochloride)
- CAS No.
- 1361504-77-9
- Chemical Name:
- DG172 (dihydrochloride)
- Synonyms
- DG-172;DG172 2HCl;DG-172 (hydrochloride);DG172 (dihydrochloride);(Z)-2-(2-Bromophenyl)-3-(4-(4-methylpiperazin-1-yl)phenyl)acrylonitrile dihydrochloride;(αZ)-2-Bromo-α-[[4-(4-methyl-1-piperazinyl)phenyl]methylene]benzeneacetonitriledihydrochloride;(αZ)-2-Bromo-α-[[4-(4-methyl-1-piperazinyl)phenyl]methylene]benzeneacetonitrile dihydrochloride;DG-172,DG172,DG172 dihydrochloride,PPAR,inhibit,DG 172,Inhibitor,Peroxisome proliferator-activated receptors
- CBNumber:
- CB53122342
- Molecular Formula:
- C20H21BrClN3
- Molecular Weight:
- 418.76
- MDL Number:
- MFCD29924728
- MOL File:
- 1361504-77-9.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| NFPA 704 |
|
DG172 (dihydrochloride) price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19128 | DG-172 (hydrochloride) ≥98% | 1361504-77-9 | 1mg | $29 | 2024-03-01 | Buy |
| Cayman Chemical | 19128 | DG-172 (hydrochloride) ≥98% | 1361504-77-9 | 5mg | $99 | 2024-03-01 | Buy |
| Cayman Chemical | 19128 | DG-172 (hydrochloride) ≥98% | 1361504-77-9 | 10mg | $169 | 2024-03-01 | Buy |
| Cayman Chemical | 19128 | DG-172 (hydrochloride) ≥98% | 1361504-77-9 | 25mg | $352 | 2024-03-01 | Buy |
| Tocris | 5566 | DG172dihydrochloride ≥98%(HPLC) | 1361504-77-9 | 10 | $183 | 2021-12-16 | Buy |
DG172 (dihydrochloride) Chemical Properties,Uses,Production
Description
DG-172 is an orally available inverse agonist of PPARβ/δ (IC50 = 27 nM), down-regulating transcription of ANGPTL4 in mouse myoblasts (IC50 = 9.5 nM). It alters the differentiation of bone marrow cells, augmenting GM-CSF-induced development into subsets of mature and immature dendritic cells. Inverse agonists of PPARβ/δ, including DG-172, inhibit cancer cell invasion through suppression of ANGPTL4 expression.
Uses
DG 172 Dihydrochloride is a potent peroxisome proliferator-activated receptor agonist and inhibit Angptl4 gene expression in mouse myoblasts.
References
[1]. lieber s, scheer f, meissner w, et al. (z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (dg172): an orally bioavailable pparβ/δ-selective ligand with inverse agonistic properties. j med chem. 2012 mar 22;55(6):2858-68.
[2]. lieber s, scheer f, finkernagel f, et al. the inverse agonist dg172 triggers a pparβ/δ-independent myeloid lineage shift and promotes gm-csf/il-4-induced dendritic cell differentiation. mol pharmacol. 2015 feb;87(2):162-73.
[3]. adhikary t, brandt dt, kaddatz k, et al. inverse pparβ/δ agonists suppress oncogenic signaling to the angptl4 gene and inhibit cancer cell invasion. oncogene. 2013 oct 31;32(44):5241-52.
DG172 (dihydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3717 | 55 |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2983 | 58 |