Sp-Cyclic AMPS (sodium salt)
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- CAS号:
- 142439-95-0
- 英文名:
- Sp-Cyclic AMPS (sodium salt)
- 英文别名:
- YTUKZYORDGLGPR-BIQAKYJPSA-M;Sp-Cyclic AMPS (sodium salt)
- 中文名:
- Sp-Cyclic AMPS (sodium salt)
- 中文别名:
- 化合物 T21697
- CBNumber:
- CB53152745
- 分子式:
- C10H13N5NaO5PS
- 分子量:
- 369.27
- MOL File:
- 142439-95-0.mol
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Sp-Cyclic AMPS (sodium salt)化学性质
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储存条件:
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Store at -20°C
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溶解度:
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≤25mg/ml in H2O
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形态:
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crystalline solid
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Sp-Cyclic AMPS (sodium salt)性质、用途与生产工艺
Sp-cAMPS sodium salt，一种 cAMP 类似物，是一种依赖 cAMP 的 PKA I 和 PKA II 的有效激活剂。Sp-cAMPS sodium salt 还是一种有效的竞争性磷酸二酯酶 (PDE3A) 抑制剂，Ki 为 47.6 µM。Sp-cAMPS sodium salt 以 EC50 为 40 μM 来结合 PDE10 GAF 域。
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PKA I
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PKA II
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PDE3A
47.6 μM (Ki)
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PDE10 GAF domain
50 μM (EC
50
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Treatment of hepatocytes with Sp-cAMPS, the stimulatory diastereomer of adenosine cyclic 3',5'-phosphorothioate, mimics the response seen with glucagon. The glucagon-stimulated increases in the level of Ca
2+
can be mimicked by Sp-cAMPS.
In chronic alcohol consumption (CAC) mice, direct infusion of the Sp-cAMPS (1 µg/µL) into the prefrontal cortex significantly improves or impairs, respectively, working memory performance in withdrawn and water animals.
Sp-Cyclic AMPS (sodium salt)
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Sp-Cyclic AMPS (sodium salt)
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142439-95-0, Sp-Cyclic AMPS (sodium salt) 相关搜索:
- 化合物 T21697
- 142439-95-0
- YTUKZYORDGLGPR-BIQAKYJPSA-M
- Sp-Cyclic AMPS (sodium salt)