化合物 T28615
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- CAS号:
- 71774-13-5
- 英文名:
- ADENOSINE-3',5'-CYCLIC -MONOPHOSPHOROTHIOATE
- 英文别名:
- cAMPS-Sp;(S)-Adenosine;Sp cAMPS,SpcAMPS;Rp cAMPS TEA salt;Rp-cAMPS TEA salt;Triethylammoniumsalt;camps,sp-isomer,teasalt;ADENOSINE-3',5'-CYCLIC -MONOPHOSPHOROTHIOATE;Adenosine, cyclic 3',5'-[hydrogen (S)-phosphorothioate];Adenosine-3'',5''-cyclic monophosphothioate sodium salt Sp isomer
- 中文名:
- 化合物 T28615
- 中文别名:
- 化合物 T28615;化合物 SP-CAMPS
- CBNumber:
- CB5506390
- 分子式:
- C10H12N5O5PS
- 分子量:
- 345.27
- MOL File:
- 71774-13-5.mol
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化合物 T28615化学性质
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沸点:
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648.0±65.0 °C(predicted)
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密度:
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2.38±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
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储存条件:
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Desiccate at -20°C
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酸度系数(pKa):
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-0.55±0.60(predicted)
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化合物 T28615性质、用途与生产工艺
Sp-cAMPS，一种 cAMP 类似物，是一种依赖 cAMP 的 PKA I 和 PKA II 的有效激活剂。Sp-cAMPS 还是一种有效的竞争性磷酸二酯酶 (PDE3A) 抑制剂，Ki 为 47.6 µM。Sp-cAMPS 以 EC50 为 40 μM 来结合 PDE10 GAF 域。
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PKA I
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PKA II
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PDE3A
47.6 μM (Ki)
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PDE10 GAF domain
50 μM (EC
50
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Treatment of hepatocytes with Sp-cAMPS, the stimulatory diastereomer of adenosine cyclic 3',5'-phosphorothioate, mimics the response seen with glucagon. The glucagon-stimulated increases in the level of Ca
2+
can be mimicked by Sp-cAMPS.
In chronic alcohol consumption (CAC) mice, direct infusion of the Sp-cAMPS (1 µg/µL) into the prefrontal cortex significantly improves or impairs, respectively, working memory performance in withdrawn and water animals.
化合物 T28615
上下游产品信息
上游原料
下游产品
71774-13-5, 化合物 T28615 相关搜索:
- Cyclic Nucleotide related
- 抑制剂
- C10H12N5O5PSC6H16N
- 化合物 SP-CAMPS
- 化合物 T28615
- 71774-13-5
- Sp cAMPS,SpcAMPS
- Rp-cAMPS TEA salt
- Rp cAMPS TEA salt
- Adenosine, cyclic 3',5'-[hydrogen (S)-phosphorothioate]
- Adenosine-3'',5''-cyclic monophosphothioate sodium salt Sp isomer
- ADENOSINE3,5-CYCLICMONOPHOSPHOTHIOATESP-ISOMERTRIETHYLAMMONIUMSALT,HIGHPURITY
- (S)-ADENOSINE, CYCLIC 3',5'-(HYDROGENPHOSPHOROTHIOATE) TRIETHYLAMMONIUM
- Triethylammoniumsalt
- cAMPS-Sp
- (S)-Adenosine
- ADENOSINE-3',5'-CYCLIC -MONOPHOSPHOROTHIOATE
- camps,sp-isomer,teasalt
- adenosine-3’,5’-cyclicmonophosphorothioate,sp-isomer(sp-camps),sodiumsalt