化合物 T28615
中文名称 | 化合物 T28615 |
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中文同义词 | 化合物 T28615 |
英文名称 | ADENOSINE-3',5'-CYCLIC -MONOPHOSPHOROTHIOATE |
英文同义词 | adenosine-3’,5’-cyclicmonophosphorothioate,sp-isomer(sp-camps),sodiumsalt;camps,sp-isomer,teasalt;ADENOSINE-3',5'-CYCLIC -MONOPHOSPHOROTHIOATE;(S)-Adenosine;cAMPS-Sp;Triethylammoniumsalt;(S)-ADENOSINE, CYCLIC 3',5'-(HYDROGENPHOSPHOROTHIOATE) TRIETHYLAMMONIUM;ADENOSINE3,5-CYCLICMONOPHOSPHOTHIOATESP-ISOMERTRIETHYLAMMONIUMSALT,HIGHPURITY |
CAS号 | 71774-13-5 |
分子式 | C10H12N5O5PS |
分子量 | 345.27 |
EINECS号 | |
相关类别 | Cyclic Nucleotide related |
Mol文件 | 71774-13-5.mol |
结构式 | ![]() |
化合物 T28615 性质
储存条件 | Desiccate at -20°C |
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PKA I
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PKA II
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PDE3A 47.6 μM (Ki) |
PDE10 GAF domain 50 μM (EC 50 ) |
Treatment of hepatocytes with Sp-cAMPS, the stimulatory diastereomer of adenosine cyclic 3',5'-phosphorothioate, mimics the response seen with glucagon. The glucagon-stimulated increases in the level of Ca 2+ can be mimicked by Sp-cAMPS.
In chronic alcohol consumption (CAC) mice, direct infusion of the Sp-cAMPS (1 µg/µL) into the prefrontal cortex significantly improves or impairs, respectively, working memory performance in withdrawn and water animals.