TNF-α inhibitor
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- CAS号:
- 1049741-03-8
- 英文名:
- TNF-α inhibitor
- 英文别名:
- TNF-α Inhibitor;TNF-α inhibitor;SPD304 dihydrochloride;SPD304 dihydrochloride,SPD-304 dihydrochloride
- 中文名:
- TNF-α inhibitor
- 中文别名:
- 化合物 T12985;化合物二盐酸SPD304
- CBNumber:
- CB55423098
- 分子式:
- C32H33ClF3N3O2
- 分子量:
- 584.08
- MOL File:
- 1049741-03-8.mol
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TNF-α inhibitor化学性质
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储存条件:
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4°C, away from moisture
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溶解度:
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DMSO : 11.36 mg/mL (18.31 mM; ultrasonic and warming and heat to 60°C)
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形态:
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White powder solid.
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颜色:
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White to off-white
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TNF-α inhibitor性质、用途与生产工艺
SPD304 dihydrochloride 是肿瘤坏死因子 α (TNF-α) 的选择性抑制剂，能够促进肿瘤坏死因子三聚体的分离，从而阻断其与受体间的相互作用。SPD304 体外抑制肿瘤坏死因子 α 和受体 1 间结合的 IC50 值为 22 µM。
SPD304 (2 μM) significantly rescues the survivability of aHSCs, reduces the production of lipid hydroxides, and increased intracellular GSH. The co-treatment of GA (75 μM) and SPD304 (2 μM), down-regulate TRADD almost 2-fold (w/o inhibitor vs. w/ inhibitor) and p−RIP3 1.4−fold compared to GA alone, and promotes caspase 8 activation.
SPD304 cannot be used in vivo due to its high toxicity.
TNF-α inhibitor
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-111255A | SPD304 dihydrochloride | | 5 mg | 1800元 |
| 2024/04/30 | HY-111255A | SPD304 dihydrochloride | | 10 mg | 2800元 |
1049741-03-8, TNF-α inhibitor 相关搜索:
- 化合物二盐酸SPD304
- 化合物 T12985
- 1049741-03-8
- TNF-α Inhibitor
- SPD304 dihydrochloride,SPD-304 dihydrochloride
- TNF-α inhibitor
- SPD304 dihydrochloride