N2,N3-双(4-氟苯基)喹喔啉-2,3-二胺
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- CAS号:
- 195822-23-2
- 英文名:
- LQZ-7I
- 英文别名:
- LQZ-7I;N2,N3-Bis(4-fluorophenyl)quinoxaline-2,3-diamine;2,3-Quinoxalinediamine, N2,N3-bis(4-fluorophenyl)-;LQZ7I,inhibit,Survivin,LQZ 7I,Inhibitor,tumor,LQZ-7I,dimerization
- 中文名:
- N2,N3-双(4-氟苯基)喹喔啉-2,3-二胺
- 中文别名:
- 化合物LQZ-7I;N2,N3-双(4-氟苯基)喹喔啉-2,3-二胺
- CBNumber:
- CB56193512
- 分子式:
- C20H14F2N4
- 分子量:
- 348.35
- MOL File:
- 195822-23-2.mol
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N2,N3-双(4-氟苯基)喹喔啉-2,3-二胺化学性质
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熔点:
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203 °C(Solv: ethanol (64-17-5))
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沸点:
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470.3±45.0 °C(Predicted)
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密度:
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1.390±0.06 g/cm3(Predicted)
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储存条件:
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Keep in dark place,Inert atmosphere,Room temperature
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溶解度:
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DMSO: 125 mg/mL (358.83 mM)
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形态:
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A solid
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酸度系数(pKa):
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2.56±0.59(Predicted)
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颜色:
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Light yellow to green yellow
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N2,N3-双(4-氟苯基)喹喔啉-2,3-二胺性质、用途与生产工艺
LQZ-7I 是一种靶向 survivin 的抑制剂。LQZ-7I 抑制生存素二聚化。LQZ-7I 口服有效抑制异种移植肿瘤生长并诱导肿瘤中生存素的损失。
LQZ-7I has improved cytotoxicity with IC
50
s of 3.1 µM against C4-2 cells and 4.8 µM against PC-3 cells compared with the parent compound LQZ-7.
LQZ-7I (10 µM; 0-6 hours) treatment reduces the expression of survivin. However, LQZ-7I does not reduce the expression of XIAP, CIAP1, and CIAP2. LQZ-7I may be selective to its intended target survivin.
Western Blot Analysis
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Cell Line:
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PC-3 or C4-2 cells
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Concentration:
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10 µM
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Incubation Time:
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0-6 hours
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Result:
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Reduced the expression of survivin.
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LQZ-7I (100 mg/kg; oral gavage every other day for a total of ten treatments) significantly suppresses tumor growth without any notable adverse effect on the mice.
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Animal Model:
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6-week old male NSG mice
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Dosage:
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100 mg/kg; 200 µL vehicle (90% corn oil/10% DMSO)
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Administration:
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Oral gavage every other day for a total of ten treatments
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Result:
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Significantly suppressed tumor growth without any notable adverse effect on the mice as indicated by lacking changes in body weight and in wet weight of major organs at the end of the study.
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N2,N3-双(4-氟苯基)喹喔啉-2,3-二胺
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-136538 | N2,N3-双(4-氟苯基)喹喔啉-2,3-二胺
LQZ-7I | 195822-23-2 | 5mg | 600元 |
| 2024/04/30 | HY-136538 | N2,N3-双(4-氟苯基)喹喔啉-2,3-二胺
LQZ-7I | 195822-23-2 | 10mM * 1mLin DMSO | 660元 |
N2,N3-双(4-氟苯基)喹喔啉-2,3-二胺
生产厂家
195822-23-2, N2,N3-双(4-氟苯基)喹喔啉-2,3-二胺 相关搜索:
- 高端化学
- 化合物LQZ-7I
- N2,N3-双(4-氟苯基)喹喔啉-2,3-二胺
- 195822-23-2
- LQZ7I,inhibit,Survivin,LQZ 7I,Inhibitor,tumor,LQZ-7I,dimerization
- N2,N3-Bis(4-fluorophenyl)quinoxaline-2,3-diamine
- 2,3-Quinoxalinediamine, N2,N3-bis(4-fluorophenyl)-
- LQZ-7I