ChemicalBook >> CAS DataBase List >>LQZ-7I
LQZ-7I
- CAS No.
- 195822-23-2
- Chemical Name:
- LQZ-7I
- Synonyms
- LQZ-7I;N2,N3-Bis(4-fluorophenyl)quinoxaline-2,3-diamine;2,3-Quinoxalinediamine, N2,N3-bis(4-fluorophenyl)-;LQZ7I,inhibit,Survivin,LQZ 7I,Inhibitor,tumor,LQZ-7I,dimerization
- CBNumber:
- CB56193512
- Molecular Formula:
- C20H14F2N4
- Molecular Weight:
- 348.35
- MDL Number:
- MFCD00607076
- MOL File:
- 195822-23-2.mol
Last updated:2024-07-02 08:55:11
| Melting point | 203 °C(Solv: ethanol (64-17-5)) |
|---|---|
| Boiling point | 470.3±45.0 °C(Predicted) |
| Density | 1.390±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | DMSO: 125 mg/mL (358.83 mM) |
| form | A solid |
| pka | 2.56±0.59(Predicted) |
| color | Light yellow to green yellow |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302+H312+H332-H314 |
| Precautionary statements | P501-P261-P270-P271-P264-P280-P362+P364-P303+P361+P353-P301+P330+P331-P301+P312+P330-P304+P340+P310-P305+P351+P338+P310-P405 |
LQZ-7I price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Ambeed | A1275711 | N2,N3-Bis(4-fluorophenyl)quinoxaline-2,3-diamine 98+% | 195822-23-2 | 1mg | $58 | 2021-12-16 | Buy |
| Arctom | AS711703 | N2,N3-Bis(4-fluorophenyl)quinoxaline-2,3-diamine ≥98% | 195822-23-2 | 5mg | $89 | 2021-12-16 | Buy |
| Ambeed | A1275711 | N2,N3-Bis(4-fluorophenyl)quinoxaline-2,3-diamine 98+% | 195822-23-2 | 5mg | $90 | 2021-12-16 | Buy |
| Arctom | AS711703 | N2,N3-Bis(4-fluorophenyl)quinoxaline-2,3-diamine ≥98% | 195822-23-2 | 10mg | $139 | 2021-12-16 | Buy |
| Ambeed | A1275711 | N2,N3-Bis(4-fluorophenyl)quinoxaline-2,3-diamine 98+% | 195822-23-2 | 10mg | $140 | 2021-12-16 | Buy |
LQZ-7I Chemical Properties,Uses,Production
Biological Activity
LQZ-7I is an inhibitor targeting survivin. It can inhibits survivin dimerization and xenograft tumor growth and induces loss of survivin in the tumor.
in vitro
LQZ-7I has improved cytotoxicity with IC 50 s of 3.1 μM against C4-2 cells and 4.8 μM against PC-3 cells compared with the parent compound LQZ-7.
LQZ-7I (10 μM; 0-6 hours) treatment reduces the expression of survivin. However, LQZ-7I does not reduce the expression of XIAP, CIAP1, and CIAP2. LQZ-7I may be selective to its intended target survivin .
Western Blot Analysis
| Cell Line: | PC- 3 or C4-2 cells |
| Concentration: | 10 μM | Incubation Time: | 0-6 hours |
| Result: | Reduced the expression of survivin. |
in vivo
LQZ-7I (100 mg/kg; oral gavage every other day for a total of ten treatments) significantly suppresses tumor growth without any notable adverse effect on the mice.
| Animal Model: | 6-week old male NSG mice |
| Dosage: | 100 mg/kg; 200 μL vehicle (90% corn oil/10% DMSO) |
| Administration: | td>Oral gavage every other day for a total of ten treatments |
| Result: | Significantly suppressed tumor growth without any notable adverse effect on the mice as indicated by lacking changes in body weight and in wet weight of major organs at the end of the study. |
target
Survivin
LQZ-7I Preparation Products And Raw materials
Raw materials
Preparation Products
LQZ-7I Suppliers
Global( 30)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4309 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8014 | 62 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9943 | 58 |
LQZ-7I
2,3-Quinoxalinediamine, N2,N3-bis(4-fluorophenyl)-
N2,N3-Bis(4-fluorophenyl)quinoxaline-2,3-diamine
LQZ7I,inhibit,Survivin,LQZ 7I,Inhibitor,tumor,LQZ-7I,dimerization
195822-23-2