N-ACETYL LYSYLTYROSYLCYSTEINE AMIDE
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- CAS号:
- 1287585-40-3
- 英文名:
- N-acetyl lysyltyrosylcysteine amide(Myeloperoxidase inhibitor KYC)
- 英文别名:
- Ac-Lys-Tyr-Cys-NH2;L-Cysteinamide, N2-acetyl-L-lysyl-L-tyrosyl-;N-acetyl lysyltyrosylcysteine amide(Myeloperoxidase inhibitor KYC)
- 中文名:
- N-ACETYL LYSYLTYROSYLCYSTEINE AMIDE
- 中文别名:
- 三肽抑制剂;化合物T38063
- CBNumber:
- CB56226324
- 分子式:
- C20H31N5O5S
- 分子量:
- 453.56
- MOL File:
- 1287585-40-3.mol
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N-ACETYL LYSYLTYROSYLCYSTEINE AMIDE化学性质
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沸点:
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902.5±65.0 °C(Predicted)
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密度:
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1.273±0.06 g/cm3(Predicted)
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储存条件:
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-20°C, protect from light
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酸度系数(pKa):
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9.18±0.10(Predicted)
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形态:
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Solid
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颜色:
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White to off-white
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N-ACETYL LYSYLTYROSYLCYSTEINE AMIDE性质、用途与生产工艺
N-Acetyl lysyltyrosylcysteine amide 是一种有效的，可逆的，特异性且无毒的髓过氧化物酶 (MPO) 三肽抑制剂。N-Acetyl lysyltyrosylcysteine amide 在体内可有效抑制 MPO 产生有毒氧化剂。N-Acetyl lysyltyrosylcysteine amide 减轻中风后大脑的神经元损伤，并保留脑组织和神经功能。N-Acetyl lysyltyrosylcysteine amide 抑制MPO依赖性次氯酸 (HOCl) 的生成，蛋白质硝化和 LDL 氧化。
N-Acetyl lysyltyrosylcysteine amide (KYC) significantly decreases infarct size, blood-brain barrier leakage, infiltration of myeloid cells, loss of neurons, and apoptosis in the brains of middle cerebral artery occlusion (MCAO) mice.
N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily for 3-7 days) significantly reduces neurological severity scores and infarct size in MCAO mice.
N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily 7 days) significantly protects BBB function and decreased neutrophil infiltration. N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily 7 days) significantly reduces microglia/macrophage activation and neuron loss in MCAO mice. N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily for 3-7 days) decreases apoptosis and cell injury in the brains of MCAO mice. N-Acetyl lysyltyrosylcysteine amide reduced MPO in the brains of MCAO mice. N-Acetyl lysyltyrosylcysteine amide reduces NO2Tyr and 4-HNE in MCAO mice.
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Animal Model:
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8-10 weeks old C57BL/6J mice (middle cerebral artery occlusion (MCAO) mode)
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Dosage:
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10 mg/kg
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Administration:
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I.p.; daily for 3-7 days
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Result:
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Significantly reduced neurological deficit and brain infarct size in mice subjected to MCAO.
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N-ACETYL LYSYLTYROSYLCYSTEINE AMIDE
上下游产品信息
上游原料
下游产品
N-ACETYL LYSYLTYROSYLCYSTEINE AMIDE
生产厂家
1287585-40-3, N-ACETYL LYSYLTYROSYLCYSTEINE AMIDE 相关搜索:
- 目录肽
- 科研试剂
- 化合物T38063
- 三肽抑制剂
- 1287585-40-3
- Ac-Lys-Tyr-Cys-NH2
- L-Cysteinamide, N2-acetyl-L-lysyl-L-tyrosyl-
- N-acetyl lysyltyrosylcysteine amide(Myeloperoxidase inhibitor KYC)