ITE
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- CAS号:
- 448906-42-1
- 英文名:
- ITE
- 英文别名:
- ITE;ITE, 10 mM in DMSO;ARYL HYDROCARBON RECEPTOR LIGAND;ITE,Aryl Hydrocarbon Receptor,Inhibitor,inhibit,AhR;Methyl 2-(1H-indole-3-carbonyl)thiazole-4-carboxylate;2-(1'H-INDOLE-3'-CARBONYL)-THIAZOLE-4-CARBOXYLIC ACID;methyl 2-(1H-indole-3-carbonyl)-1,3-thiazole-4-carboxylate;2-(1H-INDOL-3-YLCARBONYL)-4-THIAZOLECARBOXYLIC ACID METHYL ESTER;2-(1'H-indole-37-carbonyl)-thiasole-4-carboxylic acid methyl ester;4-Thiazolecarboxylic acid, 2-(1H-indol-3-ylcarbonyl)-, methyl ester
- 中文名:
- ITE
- 中文别名:
- 化合物ITE;芳香烃受体(AHR)激动剂(ITE);ITE,内源性芳烃受体(AHR)激动剂;化合物ITE,10 MM DMSO 溶液;2-(1H-吲哚-3-基羰基)-4-噻唑羧酸甲酯;甲基 2-(1H-吲哚-3-羰基)-1,3-噻唑-4-甲酸基酯
- CBNumber:
- CB5754713
- 分子式:
- C14H10N2O3S
- 分子量:
- 286.31
- MOL File:
- 448906-42-1.mol
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ITE化学性质
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熔点:
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234 - 236°C
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沸点:
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520.4±48.0 °C(Predicted)
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密度:
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1.427±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: 30 mg/mL, soluble
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酸度系数(pKa):
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14.38±0.30(Predicted)
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形态:
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solid
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颜色:
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Off-White to Light Yellow
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ITE性质、用途与生产工艺
ITE是一种芳香烃受体(AhR)激动剂,Ki值为3nM,ITE作用于OVCAR-3细胞增殖为,IC50值为0.2nM。
ITE 是一种有效的内源性芳香烃受体 (AhR) 激动剂，能够直接与 AHR 结合，Ki 值为 3 nM。ITE 具有免疫抑制作用。
ITE is an endogenous agonist of AhR, binding directly to AHR, with a K
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of 3 nM. ITE (0.03-30 mg/mL) decreases the antigen-specific T-cell proliferative responses. ITE potently inhibits human pulmonary artery endothelial (HPAECs) growth at 10 and 20 µM, but shows no effect at 0.01-5 µM. ITE does not affect cell cycle progress of HPAECs at 10 and 20 µM, or induce expression of cleaved caspase-3 protein in HPAECs at 20 µM. In addition, ITE (20 µM) elevates CYP1A1 and CYP1B1 mRNA levels and decreases the levels of AhR protein in HPAECs.
ITE (200 μg, i.p.) significantly suppresses the development of experimental autoimmune uveitis (EAU) in mice. ITE reduces the proportions of cells expressing IFN-γ, IL-17, or IL-10 in mice. ITE also suppresses the secretion of inflammatory cytokines by LN cells in mice.
ITE
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上游原料
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ITE
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全球有 101家供应商
ITE国内生产厂家
448906-42-1, ITE 相关搜索:
- 抑制剂
- 药靶配体
- 化工原料
- 细胞生物学试剂
- C14H10N2O3S
- 化合物ITE,10 MM DMSO 溶液
- ITE,内源性芳烃受体(AHR)激动剂
- 甲基 2-(1H-吲哚-3-羰基)-1,3-噻唑-4-甲酸基酯
- 化合物ITE
- 芳香烃受体(AHR)激动剂(ITE)
- 2-(1H-吲哚-3-基羰基)-4-噻唑羧酸甲酯
- 448906-42-1
- ITE, 10 mM in DMSO
- ITE,Aryl Hydrocarbon Receptor,Inhibitor,inhibit,AhR
- 4-Thiazolecarboxylic acid, 2-(1H-indol-3-ylcarbonyl)-, methyl ester
- ARYL HYDROCARBON RECEPTOR LIGAND
- methyl 2-(1H-indole-3-carbonyl)-1,3-thiazole-4-carboxylate
- Methyl 2-(1H-indole-3-carbonyl)thiazole-4-carboxylate
- 2-(1'H-indole-37-carbonyl)-thiasole-4-carboxylic acid methyl ester
- 2-(1'H-INDOLE-3'-CARBONYL)-THIAZOLE-4-CARBOXYLIC ACID
- 2-(1H-INDOL-3-YLCARBONYL)-4-THIAZOLECARBOXYLIC ACID METHYL ESTER
- ITE