4-氯-2-甲基苯基硫氰酸酯
|
|
|
- CAS号:
- 86030-08-2
- 英文名:
- 4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE
- 英文别名:
- BTB-1;NSC156750;BTB 1; BTB1;LABOTEST-BB LT01147747;BTB 1 - NSC 156750 | NSC 658180;4-CHLORO-2-NITRODIPHENYL SULFONE;4-Chloro-2-nitrodiphenyl sulphone;4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE;1-Benzenesulfonyl-4-chloro-2-nitro-benzene;4-chloro-2-nitro-1-(phenylsulphonyl)benzene
- 中文名:
- 4-氯-2-甲基苯基硫氰酸酯
- 中文别名:
- 化合物BTB1;BTB1,KIF18A抑制剂;KIF18A抑制剂(BTB-1);4-氯-2-硝基-1-(苯基磺酰基)苯
- CBNumber:
- CB5783210
- 分子式:
- C12H8ClNO4S
- 分子量:
- 297.71
- MOL File:
- 86030-08-2.mol
|
|
|
4-氯-2-甲基苯基硫氰酸酯化学性质
-
熔点:
-
115 °C
-
|
-
沸点:
-
471.2±35.0 °C(Predicted)
-
|
-
密度:
-
1.476±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
Sealed in dry,Room Temperature
-
|
-
溶解度:
-
Soluble in DMSO (30 mg/ml)
-
|
-
形态:
-
solid
-
|
-
颜色:
-
White to off-white
-
|
-
稳定性:
-
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
-
|
4-氯-2-甲基苯基硫氰酸酯性质、用途与生产工艺
BTB-1 是一种新型的、可逆的选择性 mitotic motor protein Kif18A 抑制剂，其IC50值为1.69 μM。
| Target | Value |
Kif18A
(Cell-free assay)
|
1.69 μM
|
BTB-1 blocks the motility of Kif18A in a reversible manner. BTB-1 inhibits Kif18A in an adenosine triphosphate (ATP)-competitive but microtubule-uncompetitive manner and slows down the progression of cells through mitosis. 100 μM BTB-1 does not significantly inhibit any of the other tested mitotic kinesins. BTB-1 competes with ATP for Kif18A binding only when the motor-protein is associated with its pseudosubstrate microtubules. HeLa cells treated with BTB-1 accumulate in mitosis in a dose-dependent manner. BTB-1 shows cell toxicity with an EC
50
values of 35.8 μM. HeLa cells treated with 50 μM BTB-1 reveals severe defects in spindle morphology and chromosome alignment. Treatment with high concentrations of BTB-1 does not result in elongated spindles.
4-氯-2-甲基苯基硫氰酸酯
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-101770 | BTB-1 | | 1 mg | 264元 |
| 2024/04/30 | HY-101770 | 4-氯-2-甲基苯基硫氰酸酯
BTB-1 | 86030-08-2 | 5mg | 550元 |
86030-08-2, 4-氯-2-甲基苯基硫氰酸酯 相关搜索:
- 药靶配体
- 标准品
- 细胞生物学试剂
- BTB1,KIF18A抑制剂
- 化合物BTB1
- KIF18A抑制剂(BTB-1)
- 4-氯-2-硝基-1-(苯基磺酰基)苯
- 86030-08-2
- Inhibitor,BTB-1,inhibit,BTB1,Microtubule/Tubulin
- Benzene, 4-chloro-2-nitro-1-(phenylsulfonyl)-
- NSC156750
- 1-(2,4-dichlorophenyl)-1-cyclopropanecarboxylic acid
- BTB 1; BTB1
- BTB 1 - NSC 156750 | NSC 658180
- BTB-1
- 4-Chloro-2-nitrodiphenyl sulphone
- 1-Benzenesulfonyl-4-chloro-2-nitro-benzene
- 4-chloro-2-nitro-1-(phenylsulphonyl)benzene
- 4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE
- 4-CHLORO-2-NITRODIPHENYL SULFONE
- LABOTEST-BB LT01147747