N-(4-氯苯基)-4-(1H-吲哚-4-基)哌嗪-1-甲酰胺
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- CAS号:
- 732973-87-4
- 英文名:
- GOT1 inhibitor 2c
- 英文别名:
- GOT1 inhibitor-1;GOT1 inhibitor 2c;N-(4-chlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide;1-Piperazinecarboxamide, N-(4-chlorophenyl)-4-(1H-indol-4-yl)-;GOT1 inhibitor1,inhibit,GOT-1 inhibitor-1,glutamate-oxaloacetate transaminase 1,Cancer,Pancreatic,GOT1,metabolism,?Aspartate aminotransferase-1,ductal,Inhibitor,GOT1 inhibitor 1,PDAC,adenocarcinoma,GOT1 inhibitor-1
- 中文名:
- N-(4-氯苯基)-4-(1H-吲哚-4-基)哌嗪-1-甲酰胺
- 中文别名:
- GOT1抑制剂2C;化合物GOT1 INHIBITOR-1;N-(4-氯苯基)-4-(1H-吲哚-4-基)哌嗪-1-甲酰胺
- CBNumber:
- CB58059447
- 分子式:
- C19H19ClN4O
- 分子量:
- 354.83
- MOL File:
- 732973-87-4.mol
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N-(4-氯苯基)-4-(1H-吲哚-4-基)哌嗪-1-甲酰胺化学性质
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沸点:
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639.5±55.0 °C(Predicted)
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密度:
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1.387±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 125 mg/mL (352.28 mM)
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酸度系数(pKa):
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13.07±0.70(Predicted)
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形态:
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Solid
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颜色:
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Off-white to light yellow
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水溶解性:
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Water: < 0.1 mg/mL (insoluble)
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N-(4-氯苯基)-4-(1H-吲哚-4-基)哌嗪-1-甲酰胺性质、用途与生产工艺
GOT1 inhibitor-1 (compound 2c) 是一种戊酸衍生物,是一种新型的、有效的、非共价的谷氨酸草酰乙酸转氨酶 1 (GOT1) 抑制剂,IC50 为 8.2 uM。 GOT1 inhibitor-1 可用于胰腺导管腺癌 (PDAC) 的研究。
PDAC tumors are dependent upon a metabolic pathway involving aspartate aminotransferase 1 (glutamate-oxaloacetate transaminase 1 (GOT1)), for the maintenance of redox homeostasis and sustained proliferation. Small molecule inhibitors targeting this metabolic pathway may provide a novel way for cancer research.
In the MDH coupled GOT1 enzymatic assay, GOT1 inhibitor-1 shows an inhibitory effect on GOT1 activity with an IC
50
value of 8.2 uM.
N-(4-氯苯基)-4-(1H-吲哚-4-基)哌嗪-1-甲酰胺
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-122723 | GOT1 inhibitor-1 | | 1 mg | 1000元 |
2024/08/19 | HY-122723 | N-(4-氯苯基)-4-(1H-吲哚-4-基)哌嗪-1-甲酰胺 GOT1 inhibitor-1 | 732973-87-4 | 5mg | 2500元 |
N-(4-氯苯基)-4-(1H-吲哚-4-基)哌嗪-1-甲酰胺
生产厂家
732973-87-4, N-(4-氯苯基)-4-(1H-吲哚-4-基)哌嗪-1-甲酰胺 相关搜索:
- 抑制剂
- 药靶配体
- GOT1抑制剂2C
- 化合物GOT1 INHIBITOR-1
- N-(4-氯苯基)-4-(1H-吲哚-4-基)哌嗪-1-甲酰胺
- 732973-87-4
- 1-Piperazinecarboxamide, N-(4-chlorophenyl)-4-(1H-indol-4-yl)-
- GOT1 inhibitor1,inhibit,GOT-1 inhibitor-1,glutamate-oxaloacetate transaminase 1,Cancer,Pancreatic,GOT1,metabolism,?Aspartate aminotransferase-1,ductal,Inhibitor,GOT1 inhibitor 1,PDAC,adenocarcinoma,GOT1 inhibitor-1
- GOT1 inhibitor 2c
- GOT1 inhibitor-1
- N-(4-chlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide