N-(4-氯苯基)-4-(1H-吲哚-4-基)哌嗪-1-甲酰胺
中文名称 | N-(4-氯苯基)-4-(1H-吲哚-4-基)哌嗪-1-甲酰胺 |
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中文同义词 | N-(4-氯苯基)-4-(1H-吲哚-4-基)哌嗪-1-甲酰胺;化合物GOT1 INHIBITOR-1;GOT1抑制剂2C |
英文名称 | GOT1 inhibitor 2c |
英文同义词 | N-(4-chlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide;GOT1 inhibitor-1;GOT1 inhibitor 2c;GOT1 inhibitor1,inhibit,GOT-1 inhibitor-1,glutamate-oxaloacetate transaminase 1,Cancer,Pancreatic,GOT1,metabolism,?Aspartate aminotransferase-1,ductal,Inhibitor,GOT1 inhibitor 1,PDAC,adenocarcinoma,GOT1 inhibitor-1;1-Piperazinecarboxamide, N-(4-chlorophenyl)-4-(1H-indol-4-yl)- |
CAS号 | 732973-87-4 |
分子式 | C19H19ClN4O |
分子量 | 354.83 |
EINECS号 | |
相关类别 | |
Mol文件 | 732973-87-4.mol |
结构式 |
N-(4-氯苯基)-4-(1H-吲哚-4-基)哌嗪-1-甲酰胺 性质
沸点 | 639.5±55.0 °C(Predicted) |
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密度 | 1.387±0.06 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 二甲基亚砜:125 mg/mL(352.28 mM) |
酸度系数(pKa) | 13.07±0.70(Predicted) |
形态 | 固体 |
颜色 | 米白色至浅黄色 |
水溶解性 | Water: < 0.1 mg/mL (insoluble) |
PDAC tumors are dependent upon a metabolic pathway involving aspartate aminotransferase 1 (glutamate-oxaloacetate transaminase 1 (GOT1)), for the maintenance of redox homeostasis and sustained proliferation. Small molecule inhibitors targeting this metabolic pathway may provide a novel way for cancer research. In the MDH coupled GOT1 enzymatic assay, GOT1 inhibitor-1 shows an inhibitory effect on GOT1 activity with an IC 50 value of 8.2 uM.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-122723 | GOT1 inhibitor-1 | 1 mg | 1000元 | |
2024/08/19 | HY-122723 | N-(4-氯苯基)-4-(1H-吲哚-4-基)哌嗪-1-甲酰胺 GOT1 inhibitor-1 | 732973-87-4 | 5mg | 2500元 |