化合物UTL-5G
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- CAS号:
- 646530-37-2
- 英文名:
- 3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-
- 英文别名:
- GBL-5g;UGL-5g;UTL-5g;N-(2,4-Dichlorophenyl)-5-methylisoxazole-3-carboxamide;3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-;liver,inhibit,Inhibitor,chemoprotective,Tumor Necrosis Factor Receptor,radioprotective,acute,toxicity,hepatotoxicity,anti-inflammatory,TNF Receptor,UTL 5g,UTL5g,TNFR,UTL-5g
- 中文名:
- 化合物UTL-5G
- 中文别名:
- 化合物UTL-5G;N-(2,4-二氯苯基)-5-甲基异恶唑-3-甲酰胺
- CBNumber:
- CB58146679
- 分子式:
- C11H8Cl2N2O2
- 分子量:
- 271.1
- MOL File:
- 646530-37-2.mol
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化合物UTL-5G化学性质
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沸点:
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336.2±42.0 °C(Predicted)
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密度:
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1.469±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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酸度系数(pKa):
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9.45±0.70(Predicted)
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形态:
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Solid
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颜色:
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White to off-white
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化合物UTL-5G性质、用途与生产工艺
UTL-5g (GBL-5g) 是一种抗炎性 TNF-α 抑制剂，具有化学保护和肝脏放射保护作用。UTL-5g 通过抑制 TNF-α 等因子降低顺铂引起的肝毒性、肾毒性和骨髓毒性。
RAW 264.7 macrophages are transfected with the respective reporter assay plasmids, pretreated with UTL-5g at 1, 10 or 50 µM for 60 min and then challenged with 100 ng/ml LPS. After a 16 h incubation, transcription factor activity is measured. Transcription factors that shows a UTL-5g dose-dependent decrease in activity in two experiments are categorized as being disrupted by UTL-5g.
UTL-5g (GBL-5g) lowers levels of TGF-β and TNF-α elevated by lung irradiation.
UTL-5g (60 mg/kg; p.o.; daily for 4 days) shows positive effects in increasing the survival rates and extending the survival times.
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Animal Model:
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C57BL/6, male mice (8-10 weeks)
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Dosage:
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15, 30, and 60 mg/kg
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Administration:
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I.p.; before irradiation, daily x 5
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Result:
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Blood levels of TGF-β were lowered.
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Animal Model:
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BDF1 female mice
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Dosage:
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P.o.; daily for 4 days
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Administration:
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60 mg/kg (30 min before i.p. injection of Cisplatin at 10, 15, and 20 mg/kg respectively on Day 0)
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Result:
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Increased the survival rate and delayed the time to death for mice treated with 150% of the maximum tolerated dose (MTD) of Cisplatin (15 mg/kg). At 200% of the MTD of Cisplatin (20 mg/kg), treatment of UTL-5g increased the survival rate and delayed the time to death.
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化合物UTL-5G
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | S3540 | 化合物UTL-5G
UTL-5g | 646530-37-2 | 25mg | 6118.62元 |
| 2024/01/25 | HY-117082 | UTL-5g | | 1 mg | 750元 |
646530-37-2, 化合物UTL-5G 相关搜索:
- 药靶配体
- N-(2,4-二氯苯基)-5-甲基异恶唑-3-甲酰胺
- 化合物UTL-5G
- 646530-37-2
- N-(2,4-Dichlorophenyl)-5-methylisoxazole-3-carboxamide
- liver,inhibit,Inhibitor,chemoprotective,Tumor Necrosis Factor Receptor,radioprotective,acute,toxicity,hepatotoxicity,anti-inflammatory,TNF Receptor,UTL 5g,UTL5g,TNFR,UTL-5g
- GBL-5g
- UGL-5g
- UTL-5g
- 3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-