化合物UTL-5G
| 中文名称 | 化合物UTL-5G |
|---|---|
| 中文同义词 | 化合物UTL-5G;N-(2,4-二氯苯基)-5-甲基异恶唑-3-甲酰胺 |
| 英文名称 | 3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl- |
| 英文同义词 | 3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-;UTL-5g;UGL-5g;GBL-5g;liver,inhibit,Inhibitor,chemoprotective,Tumor Necrosis Factor Receptor,radioprotective,acute,toxicity,hepatotoxicity,anti-inflammatory,TNF Receptor,UTL 5g,UTL5g,TNFR,UTL-5g;N-(2,4-Dichlorophenyl)-5-methylisoxazole-3-carboxamide |
| CAS号 | 646530-37-2 |
| 分子式 | C11H8Cl2N2O2 |
| 分子量 | 271.1 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 646530-37-2.mol |
| 结构式 |  |
化合物UTL-5G 性质
| 沸点 | 336.2±42.0 °C(Predicted) |
|---|---|
| 密度 | 1.469±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 酸度系数(pKa) | 9.45±0.70(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
UTL-5g (GBL-5g) 是一种抗炎性 TNF-α 抑制剂，具有化学保护和肝脏放射保护作用。UTL-5g 通过抑制 TNF-α 等因子降低顺铂引起的肝毒性、肾毒性和骨髓毒性。
RAW 264.7 macrophages are transfected with the respective reporter assay plasmids, pretreated with UTL-5g at 1, 10 or 50 µM for 60 min and then challenged with 100 ng/ml LPS. After a 16 h incubation, transcription factor activity is measured. Transcription factors that shows a UTL-5g dose-dependent decrease in activity in two experiments are categorized as being disrupted by UTL-5g.
UTL-5g (GBL-5g) lowers levels of TGF-β and TNF-α elevated by lung irradiation.
UTL-5g (60 mg/kg; p.o.; daily for 4 days) shows positive effects in increasing the survival rates and extending the survival times.
| Animal Model: | C57BL/6, male mice (8-10 weeks) |
| Dosage: | 15, 30, and 60 mg/kg |
| Administration: | I.p.; before irradiation, daily x 5 |
| Result: | Blood levels of TGF-β were lowered. |
| Animal Model: | BDF1 female mice |
| Dosage: | P.o.; daily for 4 days |
| Administration: | 60 mg/kg (30 min before i.p. injection of Cisplatin at 10, 15, and 20 mg/kg respectively on Day 0) |
| Result: | Increased the survival rate and delayed the time to death for mice treated with 150% of the maximum tolerated dose (MTD) of Cisplatin (15 mg/kg). At 200% of the MTD of Cisplatin (20 mg/kg), treatment of UTL-5g increased the survival rate and delayed the time to death. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-117082 | UTL-5g | 1 mg | 750元 | |
| 2024/08/19 | HY-117082 | 化合物UTL-5G UTL-5g | 646530-37-2 | 5mg | 1800元 |