哌卡嗪
|
|
|
- CAS号:
- 60-89-9
- 英文名:
- pecazine
- 英文别名:
- Paxital;Pecatal;Lacumin;Mepazin;MEPAZINE;Pacazine;pecazine;Ai3-50131;Nothiazine;Einecs 200-490-8
- 中文名:
- 哌卡嗪
- 中文别名:
- 哌卡嗪;甲哌啶嗪;化合物 T16040
- CBNumber:
- CB5876419
- 分子式:
- C19H22N2S
- 分子量:
- 310.46
- MOL File:
- 60-89-9.mol
|
|
|
哌卡嗪化学性质
-
熔点:
-
80°C
-
|
-
沸点:
-
bp4 230-235°
-
|
-
密度:
-
1.1252 (rough estimate)
-
|
-
折射率:
-
1.6270 (estimate)
-
|
-
储存条件:
-
Hygroscopic, Refrigerator, under inert atmosphere
-
|
-
溶解度:
-
DMSO : 130 mg/mL (418.73 mM; Need ultrasonic)
-
|
-
形态:
-
Oil
-
|
-
颜色:
-
Light yellow to light brown
-
|
-
水溶解性:
-
5.588mg/L(24 ºC)
-
|
哌卡嗪性质、用途与生产工艺
Mepazine (Pecazine) 是一种有效的选择性 MALT1 蛋白酶抑制剂。Mepazine 抑制全长 GSTMALT1 和 GSTMALT1 325-760 段的 IC50 分别为 0.83 和 0.42 μM。Mepazine 通过增强细胞凋亡 (apoptosis) 来影响 ABC-DLBCL 细胞的生存能力。
Mepazine (5-20 μM; 4 days) causes a decrease of cell viability in the activated B cell subtype of diffuse large B cell lymphoma (ABCDLBCL) cells, without significantly affecting GCB-DLBCL cells.
Cell Viability Assay
|
Cell Line:
|
ABC-DLBCL cell lines (HBL1, OCI-Ly3, U2932, TMD8, OCI-Ly10) and GCB-DLBCL cell lines (BJAB, Su-DHL-6, Su-DHL-4)
|
|
Concentration:
|
5, 10, and 20 μM
|
|
Incubation Time:
|
4 days
|
|
Result:
|
Caused a decrease of cell viability in the ABC-DLBCL cells HBL1, OCI-Ly3, U2932, and TMD8, without significantly affecting GCB-DLBCL cells.
|
Mepazine (16 mg/kg; intraperitoneal administration) interferes with growth and induces apoptosis of ABC-DLBCL cell line OCI-Ly10 in NOD/scid IL-2Rg
null
(NSG) mice with a murine DLBCL xenogeneic tumor model. Daily administration of Mepazine strongly impairs the expansion of the ABC-DLBCL cell line OCI-Ly10.
|
Animal Model:
|
6- to 8-week-old female NOD.Cg-
Prkdc
scid
Il2rg
tm1Wjl
/SzJ (NSG) mice with a murine DLBCL xenogeneic tumor model
|
|
Dosage:
|
400 μg per animal (25 g), corresponding to approximately 16 mg/kg.
|
|
Administration:
|
Intraperitoneal administration; started 1 or 12 days after transplantation and given continuously every 24 hr; daily application
|
|
Result:
|
Daily administration strongly impaired the expansion of the ABC-DLBCL cell line OCI-Ly10.
|
哌卡嗪
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | HY-121282 | Mepazine | | 25 mg | 1150元 |
| 2024/11/08 | HY-121282 | Mepazine | | 50 mg | 1750元 |
哌卡嗪
生产厂家
全球有 22家供应商
哌卡嗪国内生产厂家
60-89-9, 哌卡嗪 相关搜索:
- 抑制剂
- 化合物 T16040
- 甲哌啶嗪
- 哌卡嗪
- 60-89-9
- diffuse,B cell,inhibit,large,mucosa associated lymphoid tissue lymphoma translocation gene 1,MALT1,lymphoma,Mepazine,ABC-DLBCL,Apoptosis,Inhibitor
- 10-[(1-Methylpiperidin-3-yl)methyl]phenothiazine
- Mepazin
- Lacumin
- Einecs 200-490-8
- Ai3-50131
- 2975-36-2 (Mono-hydrochloride)
- 10H-Phenothiazine, 10-((1-methyl-3-piperidinyl)methyl)-
- 10-(1-Methylpiperidyl-3-methyl)phenothiazine
- 10-(1-Methyl-3-piperidyl)methyl phenothiazine
- (N-Methyl-3-piperidyl)methylphenothiazine
- Pecatal
- Pacazine
- pecazine
- Paxital
- Nothiazine
- 10-[(1-Methyl-3-piperidinyl)methyl]-10H-phenothiazine
- MEPAZINE