奈康唑
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- CAS号:
- 130726-68-0
- 英文名:
- Neticonazole
- 英文别名:
- Neticonazole;Neticonazolehyd;Naconazole hydrochloride;1-[(E)-2-methylsulfanyl-1-(2-pentoxyphenyl)ethenyl]imidazole;(E)-1-(2-(Methylthio)-1-(2-(pentyloxy)phenyl)vinyl)-1H-imidazole;1-[(E)-2-Methylthio-1-[2-(pentyloxy)phenyl]ethenyl]-1H-imidazole;1-[(E)-2-(Methylthio)-1-[2-(pentyloxy)phenyl]vinyl]-1H-imidazole;1-[(E)-2-(Methylthio)-1-[2-(pentyloxy)phenyl]ethenyl]-1H-imidazole;1-{(E)-2-(Methylsulfanyl)-1-[2-(pentyloxy)phenyl]vinyl}-1H-imidazole;1H-Imidazole, 1-[(1E)-2-(methylthio)-1-[2-(pentyloxy)phenyl]ethenyl]-
- 中文名:
- 奈康唑
- 中文别名:
- 奈康咗;奈康唑;奈替康唑;奈康唑杂质;奈康唑粗品;(E)-1-(2-(甲硫基)-1-(2-(戊基氧基)苯基)乙烯基)-1H-咪唑
- CBNumber:
- CB61075063
- 分子式:
- C17H22N2OS
- 分子量:
- 302.43
- MOL File:
- 130726-68-0.mol
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奈康唑化学性质
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熔点:
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37-39°
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 250 mg/mL (826.64 mM)
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形态:
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Solid
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颜色:
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White to off-white
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奈康唑性质、用途与生产工艺
Neticonazole 是一种咪唑衍生物,也是一种有效且长效的抗真菌剂。Neticonazole 具有抗感染和抗癌作用。
Neticonazole (10 µM; 48 hours; C4-2B cells) treatment decreases the levels of both Alix and Rab27a, and significantly decreases nSMase2 levels. Neticonazole causes a significant inhibition in p-ERK levels.
Neticonazole (0-10 µM) exhibits a potent and dose-dependent inhibition of exosome release from C4-2B cells.
Neticonazole is also an orally active
exosome biogenesis and secretion
inhibitor.
Western Blot Analysis
Cell Line:
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C4-2B cells
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Concentration:
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10 µM
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Incubation Time:
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48 hours
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Result:
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Decreased the levels of both Alix and Rab27a, and significantly decreased nSMase2 levels.
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Neticonazole (1-100 ng/kg; oral gavage; daily; for 15 days; male C57BL/6 mice) treatment significantly improves the survival of intestinal dysbacteriosis (IDB) mice with colorectal cancer (CRC) xenograft tumors, likely through increasing apoptosis of CRC xenograft tumor cells.
Animal Model:
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Male C57BL/6 mice (8 weeks old) given ampicillin, neomycin, metronidazole and vancomycin, and injected with SW480 cells
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Dosage:
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1 ng/kg, 10 ng/kg and 100 ng/kg
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Administration:
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Oral gavage; daily; for 15 days
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Result:
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Significantly improved the survival of IDB mice with CRC xenograft tumors.
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奈康唑
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-106541 | 奈康唑 Neticonazole | 130726-68-0 | 25mg | 750元 |
2024/04/30 | HY-106541 | 奈康唑 Neticonazole | 130726-68-0 | 10mM * 1mLin DMSO | 830元 |
奈康唑
生产厂家
全球有 48家供应商
奈康唑国内生产厂家
130726-68-0, 奈康唑 相关搜索:
- Intermediate of Neticonazole Hydrochloride
- 药靶配体
- 优势产品
- 对照品-杂质对照品
- 盐酸奈康唑中间体
- (E)-1-(2-(甲硫基)-1-(2-(戊基氧基)苯基)乙烯基)-1H-咪唑
- 奈替康唑
- 奈康唑杂质
- 奈康唑粗品
- 奈康咗
- 奈康唑
- 130726-68-0
- (E)-1-(2-(Methylthio)-1-(2-(pentyloxy)phenyl)vinyl)-1H-imidazole
- Neticonazolehyd
- Naconazole hydrochloride
- 1H-Imidazole, 1-[(1E)-2-(methylthio)-1-[2-(pentyloxy)phenyl]ethenyl]-
- 1-{(E)-2-(Methylsulfanyl)-1-[2-(pentyloxy)phenyl]vinyl}-1H-imidazole
- 1-[(E)-2-methylsulfanyl-1-(2-pentoxyphenyl)ethenyl]imidazole
- 1-[(E)-2-Methylthio-1-[2-(pentyloxy)phenyl]ethenyl]-1H-imidazole
- 1-[(E)-2-(Methylthio)-1-[2-(pentyloxy)phenyl]vinyl]-1H-imidazole
- 1-[(E)-2-(Methylthio)-1-[2-(pentyloxy)phenyl]ethenyl]-1H-imidazole
- Neticonazole