奈康唑

奈康唑

中文名称奈康唑
中文同义词奈康唑;奈康咗;奈康唑粗品;奈康唑杂质;奈替康唑;(E)-1-(2-(甲硫基)-1-(2-(戊基氧基)苯基)乙烯基)-1H-咪唑
英文名称Neticonazole
英文同义词Neticonazole;1-[(E)-2-(Methylthio)-1-[2-(pentyloxy)phenyl]ethenyl]-1H-imidazole;1-[(E)-2-(Methylthio)-1-[2-(pentyloxy)phenyl]vinyl]-1H-imidazole;1-[(E)-2-Methylthio-1-[2-(pentyloxy)phenyl]ethenyl]-1H-imidazole;1-[(E)-2-methylsulfanyl-1-(2-pentoxyphenyl)ethenyl]imidazole;1-{(E)-2-(Methylsulfanyl)-1-[2-(pentyloxy)phenyl]vinyl}-1H-imidazole;1H-Imidazole, 1-[(1E)-2-(methylthio)-1-[2-(pentyloxy)phenyl]ethenyl]-;Naconazole hydrochloride
CAS号130726-68-0
分子式C17H22N2OS
分子量302.43
EINECS号
相关类别盐酸奈康唑中间体;对照品-杂质对照品;优势产品;Intermediate of Neticonazole Hydrochloride
Mol文件130726-68-0.mol
结构式奈康唑 结构式

奈康唑 性质

熔点37-39°
储存条件Store at -20°C
溶解度二甲基亚砜:250 mg/mL(826.64 mM)
形态固体
颜色白色至米白色

奈康唑 用途与合成方法

Neticonazole 是一种咪唑衍生物,也是一种有效且长效的抗真菌剂。Neticonazole 具有抗感染和抗癌作用。

Fungal

Neticonazole (10 µM; 48 hours; C4-2B cells) treatment decreases the levels of both Alix and Rab27a, and significantly decreases nSMase2 levels. Neticonazole causes a significant inhibition in p-ERK levels.
Neticonazole (0-10 µM) exhibits a potent and dose-dependent inhibition of exosome release from C4-2B cells.
Neticonazole is also an orally active exosome biogenesis and secretion inhibitor.

Western Blot Analysis

Cell Line: C4-2B cells
Concentration: 10 µM
Incubation Time: 48 hours
Result: Decreased the levels of both Alix and Rab27a, and significantly decreased nSMase2 levels.

Neticonazole (1-100 ng/kg; oral gavage; daily; for 15 days; male C57BL/6 mice) treatment significantly improves the survival of intestinal dysbacteriosis (IDB) mice with colorectal cancer (CRC) xenograft tumors, likely through increasing apoptosis of CRC xenograft tumor cells.

Animal Model: Male C57BL/6 mice (8 weeks old) given ampicillin, neomycin, metronidazole and vancomycin, and injected with SW480 cells
Dosage: 1 ng/kg, 10 ng/kg and 100 ng/kg
Administration: Oral gavage; daily; for 15 days
Result: Significantly improved the survival of IDB mice with CRC xenograft tumors.

安全信息

MSDS信息

更新日期产品编号产品名称CAS号包装价格
2024/04/30HY-106541奈康唑
Neticonazole
130726-68-025mg750元
2024/04/30HY-106541奈康唑
Neticonazole
130726-68-010mM * 1mLin DMSO830元

奈康唑 上下游产品信息

"奈康唑"相关产品信息
伊曲康唑 伏立康唑
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