奈康唑
| 中文名称 | 奈康唑 |
|---|---|
| 中文同义词 | 奈康唑;奈康咗;奈康唑粗品;奈康唑杂质;奈替康唑;(E)-1-(2-(甲硫基)-1-(2-(戊基氧基)苯基)乙烯基)-1H-咪唑 |
| 英文名称 | Neticonazole |
| 英文同义词 | Neticonazole;1-[(E)-2-(Methylthio)-1-[2-(pentyloxy)phenyl]ethenyl]-1H-imidazole;1-[(E)-2-(Methylthio)-1-[2-(pentyloxy)phenyl]vinyl]-1H-imidazole;1-[(E)-2-Methylthio-1-[2-(pentyloxy)phenyl]ethenyl]-1H-imidazole;1-[(E)-2-methylsulfanyl-1-(2-pentoxyphenyl)ethenyl]imidazole;1-{(E)-2-(Methylsulfanyl)-1-[2-(pentyloxy)phenyl]vinyl}-1H-imidazole;1H-Imidazole, 1-[(1E)-2-(methylthio)-1-[2-(pentyloxy)phenyl]ethenyl]-;Naconazole hydrochloride |
| CAS号 | 130726-68-0 |
| 分子式 | C17H22N2OS |
| 分子量 | 302.43 |
| EINECS号 | |
| 相关类别 | 盐酸奈康唑中间体;对照品-杂质对照品;优势产品;Intermediate of Neticonazole Hydrochloride |
| Mol文件 | 130726-68-0.mol |
| 结构式 |  |
奈康唑 性质
| 熔点 | 37-39° |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：250 mg/mL（826.64 mM） |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
Fungal
Neticonazole (10 µM; 48 hours; C4-2B cells) treatment decreases the levels of both Alix and Rab27a, and significantly decreases nSMase2 levels. Neticonazole causes a significant inhibition in p-ERK levels.
Neticonazole (0-10 µM) exhibits a potent and dose-dependent inhibition of exosome release from C4-2B cells.
Neticonazole is also an orally active
exosome biogenesis and secretion
inhibitor.
Western Blot Analysis
| Cell Line: | C4-2B cells |
| Concentration: | 10 µM |
| Incubation Time: | 48 hours |
| Result: | Decreased the levels of both Alix and Rab27a, and significantly decreased nSMase2 levels. |
Neticonazole (1-100 ng/kg; oral gavage; daily; for 15 days; male C57BL/6 mice) treatment significantly improves the survival of intestinal dysbacteriosis (IDB) mice with colorectal cancer (CRC) xenograft tumors, likely through increasing apoptosis of CRC xenograft tumor cells.
| Animal Model: | Male C57BL/6 mice (8 weeks old) given ampicillin, neomycin, metronidazole and vancomycin, and injected with SW480 cells |
| Dosage: | 1 ng/kg, 10 ng/kg and 100 ng/kg |
| Administration: | Oral gavage; daily; for 15 days |
| Result: | Significantly improved the survival of IDB mice with CRC xenograft tumors. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-106541 | 奈康唑 Neticonazole | 130726-68-0 | 25mg | 750元 |
| 2024/04/30 | HY-106541 | 奈康唑 Neticonazole | 130726-68-0 | 10mM * 1mLin DMSO | 830元 |