特丁贝罗
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- CAS号:
- 56488-59-6
- 英文名:
- Terbufibrol
- 英文别名:
- K-11267;Terbufibrol;Reaxys ID: 2949416;p-[3-(p-tert-Butylphenoxy)-2-hydroxypropoxy]benzoic acid;p-[[3-(p-t-Butylphenoxy)-2-hydroxypropyl]oxy]benzoic acid;Benzoic acid, 4-[3-[4-(1,1-dimethylethyl)phenoxy]-2-hydroxypropoxy]-
- 中文名:
- 特丁贝罗
- 中文别名:
- 特丁贝罗;化合物 T13919
- CBNumber:
- CB61117028
- 分子式:
- C20H24O5
- 分子量:
- 344.4
- MOL File:
- 56488-59-6.mol
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特丁贝罗化学性质
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沸点:
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439.5°C (rough estimate)
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密度:
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1.1444 (rough estimate)
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折射率:
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1.5400 (estimate)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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4.41±0.10(Predicted)
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特丁贝罗性质、用途与生产工艺
Terbufibrol 在正常和高胆固醇血症雄性大鼠中，高效降低血清总胆固醇 (TC) 水平。
Terbufibrol (20-200 mg/kg) is active in lowering serum TC in animals on all 3 diets, but the extent of cholesterol reduction varies in the order cholesterol (HC)>high protein and fat diet (HPF)>N (max. reductions: 154, 80, and 70%, respectively). Clofibrate (200 mg/kg) decreases TC by a maximum of 28% with the HPF-diet and 13% with the N-diet but is inactive with the HC-diet. Cholestyramine (400 mg/kg/day) is inactive in HPF-fed animals but reduces TC in HC-fed animals by 45%. With the HPF-diet nicotinic acid (200 mg/kg) is inactive. Terbufibrol lowers HDL, HDL-TC, LDL, LDL-TC and LDL-TC/PL in animals fed HPF-diet. A greater decrease of LDL-TC occurres with increasing dose. The main effect of Clofibrate (200 mg/kg) is to reduce HDL and HDL-TC and to increase LDL.
类别
有毒物质
毒性分级
中毒
急性毒性
口服-大鼠 LD50: 2400 毫克/公斤; 口服-小鼠 LD50: 2100 毫克/公斤
可燃性危险特性
热分解辛辣刺激烟雾
储运特性
库房通风低温干燥
灭火剂
水, 干粉, 二氧化碳, 泡沫
特丁贝罗
上下游产品信息
上游原料
下游产品
56488-59-6, 特丁贝罗 相关搜索:
- C20H24O5
- 化合物 T13919
- 特丁贝罗
- 56488-59-6
- Benzoic acid, 4-[3-[4-(1,1-dimethylethyl)phenoxy]-2-hydroxypropoxy]-
- Reaxys ID: 2949416
- p-[3-(p-tert-Butylphenoxy)-2-hydroxypropoxy]benzoic acid
- p-[[3-(p-t-Butylphenoxy)-2-hydroxypropyl]oxy]benzoic acid
- K-11267
- Terbufibrol