CS-2408
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- CAS号:
- 148081-72-5
- 英文名:
- 1-O-Hexyl-2,3,5-trimethylhydroquinone
- 英文别名:
- CS-2408;HX-1171;4-hexoxy-2;1-O-Hexyl-2;HX-1171(HTHQ);HTHQ(HX-1171);6-trimethylphenol;HTHQ, 10 mM in DMSO;5-trimethylhydroquinone;HEXYLOXY TRIMETHYLPHENOL
- 中文名:
- CS-2408
- 中文别名:
- 化合物HTHQ;己氧基三甲基苯酚;4-己氧基-2,3,6-三甲基苯酚;1-O-己基-2,3,5-三甲基氢醌;化合物HTHQ,10 MM DMSO 溶液
- CBNumber:
- CB61175507
- 分子式:
- C15H24O2
- 分子量:
- 236.35
- MOL File:
- 148081-72-5.mol
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CS-2408化学性质
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熔点:
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72.5-73°C
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沸点:
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357.8±37.0 °C(Predicted)
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密度:
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0.971±0.06 g/cm3(Predicted)
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储存条件:
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Inert atmosphere,2-8°C
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溶解度:
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Chloroform：soluble
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形态:
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powder to crystal
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酸度系数(pKa):
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11.22±0.30(Predicted)
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颜色:
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White to Light yellow to Dark green
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LogP:
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5.255 (est)
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CS-2408性质、用途与生产工艺
HTHQ (1-O-hexyl-2,3,5-trimethylhydroquinone) 是一种强力的亲脂性酚类抗氧化剂。HTHQ 通过与活性氧 (ROS) 直接反应并清除 ROS 以形成更稳定的自由基而具有很强的抗氧化活性。
HTHQ (0-100 μM; 24 hours; PC12 cells) treatment increases cell viabilities in a dose-dependent manner.
HTHQ (10 μM; 0.6-24 hours; PC12 cells) inhibits 3,4-L-Dihydroxyphenylalanine (L-DOPA) -induced phosphorylation of sustaines extracellular signal-regulated kinases (ERK1/2), p38 mitogen-activated protein kinase (MAPK), and c-Jun N-terminal kinase (JNK1/2). HTHQ also normalizes L-DOPA-reduced Bcl-2-associated death protein (Bad) phosphorylation and Bcl-2-associated X protein (Bax) expression, promoting cell survival.
Cell Viability Assay
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Cell Line:
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PC12 cells
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Concentration:
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0 μM, 1 μM, 10 μM, and 100 μM
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Incubation Time:
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24 hours
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Result:
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Reduced cell viability at 24 hours caused by both 100 and 200 µM L-DOPA was significantly attenuated.
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Western Blot Analysis
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Cell Line:
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PC12 cells
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Concentration:
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10 μM
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Incubation Time:
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0.6-24 hours
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Result:
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Inhibited L-DOPA-induced phosphorylation of sustained extracellular signal-regulated kinases (ERK1/2), p38 mitogen-activated protein kinase (MAPK), and c-Jun N-terminal kinase (JNK1/2). And also normalized L-DOPA-reduced Bcl-2-associated death protein (Bad) phosphorylation and Bcl-2-associated X protein (Bax) expression.
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HTHQ (50-200 mg/kg; oral administration; for 4 weeks; specific pathogen-free male Sprague Dawley rats) treatment significantly improves liver weight and serum chemistry level. HTHQ reduces hydroxyproline and malondialdehyde level in the liver. HTHQ treatment also reduces fibrotic septa. HTHQ administration shows reduced mRNA level of PDGF (Plateletderived growth factor) , α-SMA (α-smooth muscle actin) and TGF-β (transforming growth factor-β) than DMN-induced hepetic fibrosis animals in the liver tissue.
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Animal Model:
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48 specific pathogen-free male Sprague Dawley (SD) rats (6-week-old ) with dimethylnitrosamine (DMN)
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Dosage:
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50 mg/kg, 100 mg/kg, 200 mg/kg
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Administration:
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Oral administration; for 4 weeks
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Result:
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Improved against DMN-induced liver fibrosis in male SD rats.
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CS-2408
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2025/02/05 | H1741 | 4-(己氧基)-2,3,6-三甲基苯酚
4-(Hexyloxy)-2,3,6-trimethylphenol | 148081-72-5 | 50mg | 230元 |
| 2025/02/05 | H1741 | 4-(己氧基)-2,3,6-三甲基苯酚
4-(Hexyloxy)-2,3,6-trimethylphenol | 148081-72-5 | 250mg | 990元 |
CS-2408
生产厂家
全球有 73家供应商
CS-2408国内生产厂家
148081-72-5, CS-2408 相关搜索:
- Mutagenesis Research Chemicals
- Detergents
- 高端化学
- 抑制剂
- 化合物HTHQ,10 MM DMSO 溶液
- 1-O-己基-2,3,5-三甲基氢醌
- 化合物HTHQ
- 4-己氧基-2,3,6-三甲基苯酚
- 己氧基三甲基苯酚
- 148081-72-5
- HTHQ, 10 mM in DMSO
- BTT 105,BTT105,inhibit,BTT-105,HTHQ,HX1171,Reactive Oxygen Species,Inhibitor,HX-1171
- HTHQ(HX-1171)
- HX-1171(HTHQ)
- HEXYLOXY TRIMETHYLPHENOL
- Phenol, 4-(hexyloxy)-2,3,6-trimethyl-
- HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone)
- CS-2408
- 4-hexoxy-2,3,6-trimethylphenol
- 6-trimethylphenol
- 5-trimethylhydroquinone
- 4-HEXOXY-2;3;6-TRIMETHYLPHENOL;1-O-HEXYL-2;3;5-TRIMETHYLHYDROQUINONE
- 4-hexoxy-2
- 1-O-Hexyl-2
- HX-1171
- 4-Hexyloxy-2,3,6-triMethylphenol
- 4-(Hexyloxy)-2,3,6-triMethyl-phenol