CS-2408
| 中文名称 | CS-2408 |
|---|---|
| 中文同义词 | 己氧基三甲基苯酚;4-己氧基-2,3,6-三甲基苯酚;化合物HTHQ;1-O-己基-2,3,5-三甲基氢醌 |
| 英文名称 | 1-O-Hexyl-2,3,5-trimethylhydroquinone |
| 英文同义词 | 4-(Hexyloxy)-2,3,6-triMethyl-phenol;4-Hexyloxy-2,3,6-triMethylphenol;HX-1171;1-O-Hexyl-2;4-hexoxy-2;4-HEXOXY-2;3;6-TRIMETHYLPHENOL;1-O-HEXYL-2;3;5-TRIMETHYLHYDROQUINONE;5-trimethylhydroquinone;6-trimethylphenol |
| CAS号 | 148081-72-5 |
| 分子式 | C15H24O2 |
| 分子量 | 236.35 |
| EINECS号 | |
| 相关类别 | 抑制剂;Detergents;Mutagenesis Research Chemicals |
| Mol文件 | 148081-72-5.mol |
| 结构式 |  |
CS-2408 性质
| 熔点 | 72.5-73°C |
|---|---|
| 沸点 | 357.8±37.0 °C(Predicted) |
| 密度 | 0.971±0.06 g/cm3(Predicted) |
| 储存条件 | Inert atmosphere,2-8°C |
| 溶解度 | 氯仿：可溶 |
| 形态 | 粉末晶体 |
| 酸度系数(pKa) | 11.22±0.30(Predicted) |
| 颜色 | 白色至淡黄色至深绿色 |
| LogP | 5.255 (est) |
ROS
HTHQ (0-100 μM; 24 hours; PC12 cells) treatment increases cell viabilities in a dose-dependent manner.
HTHQ (10 μM; 0.6-24 hours; PC12 cells) inhibits 3,4-L-Dihydroxyphenylalanine (L-DOPA) -induced phosphorylation of sustaines extracellular signal-regulated kinases (ERK1/2), p38 mitogen-activated protein kinase (MAPK), and c-Jun N-terminal kinase (JNK1/2). HTHQ also normalizes L-DOPA-reduced Bcl-2-associated death protein (Bad) phosphorylation and Bcl-2-associated X protein (Bax) expression, promoting cell survival.
Cell Viability Assay
| Cell Line: | PC12 cells |
| Concentration: | 0 μM, 1 μM, 10 μM, and 100 μM |
| Incubation Time: | 24 hours |
| Result: | Reduced cell viability at 24 hours caused by both 100 and 200 µM L-DOPA was significantly attenuated. |
Western Blot Analysis
| Cell Line: | PC12 cells |
| Concentration: | 10 μM |
| Incubation Time: | 0.6-24 hours |
| Result: | Inhibited L-DOPA-induced phosphorylation of sustained extracellular signal-regulated kinases (ERK1/2), p38 mitogen-activated protein kinase (MAPK), and c-Jun N-terminal kinase (JNK1/2). And also normalized L-DOPA-reduced Bcl-2-associated death protein (Bad) phosphorylation and Bcl-2-associated X protein (Bax) expression. |
HTHQ (50-200 mg/kg; oral administration; for 4 weeks; specific pathogen-free male Sprague Dawley rats) treatment significantly improves liver weight and serum chemistry level. HTHQ reduces hydroxyproline and malondialdehyde level in the liver. HTHQ treatment also reduces fibrotic septa. HTHQ administration shows reduced mRNA level of PDGF (Plateletderived growth factor) , α-SMA (α-smooth muscle actin) and TGF-β (transforming growth factor-β) than DMN-induced hepetic fibrosis animals in the liver tissue.
| Animal Model: | 48 specific pathogen-free male Sprague Dawley (SD) rats (6-week-old ) with dimethylnitrosamine (DMN) |
| Dosage: | 50 mg/kg, 100 mg/kg, 200 mg/kg |
| Administration: | Oral administration; for 4 weeks |
| Result: | Improved against DMN-induced liver fibrosis in male SD rats. |
安全信息
| 海关编码 | 2909.50.5000 |
|---|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | H1741 | 4-(己氧基)-2,3,6-三甲基苯酚 4-(Hexyloxy)-2,3,6-trimethylphenol | 148081-72-5 | 50mg | 210元 |
| 2024/08/19 | H1741 | 4-(己氧基)-2,3,6-三甲基苯酚 4-(Hexyloxy)-2,3,6-trimethylphenol | 148081-72-5 | 250mg | 990元 |