螺莫司汀
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- CAS号:
- 56605-16-4
- 英文名:
- Spiromustine
- 英文别名:
- SHM;NCI172112;NSC268497;NSC-172112;Spiromustine;Spiromustard;NCI172112,NCI-172112;Spiromustine USP/EP/BP;spirohydantoin mustard;Spirohydantoin masturd
- 中文名:
- 螺莫司汀
- 中文别名:
- 螺莫司汀;化合物 T12195;化合物 NCI172112
- CBNumber:
- CB61179772
- 分子式:
- C14H23Cl2N3O2
- 分子量:
- 336.26
- MOL File:
- 56605-16-4.mol
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螺莫司汀化学性质
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熔点:
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125.5°C
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密度:
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1.3876 (rough estimate)
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折射率:
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1.6070 (estimate)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形态:
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Solid
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酸度系数(pKa):
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10.53±0.20(Predicted)
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颜色:
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White to off-white
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螺莫司汀性质、用途与生产工艺
NCI172112 是一种经典的双功能烷化剂,是为了开发有效抗中枢神经系统肿瘤而合成的一种抗肿瘤剂。
NCI172112 (Spirohydantoin mustard, SHM) might serve as a carrier to cross the blood brain barrier. The cumulative excretion of radioactivity in the urine and faeces of rats after administration of [2-chloroethyl-U-
14
C]NCI172112 or [hydantoin-4-
14
C]NCI172112 ( 3.13 mg/kg. i.v.) is measured. Four hours after dosing, a significantly (P<0.005) greater amount of radioactivity has been excreted in the urine of rats treated with [hydantoin-
14
C]NCI172112 than with [ethyl-
14
C]NCI172112. However, by 24 h, approx.50% of dose is recovered in the urine with both labelled materials. Clearance of radioactivity in the faeces is slow, but, as for the renal excretion, is significantly greater for the hydantoin-
14
C moiety. No radioactivity is found in the expired air of a rat receiving a single dosing of [hydantoin-
14
C]NCI172112 and less than 1% is measured after administration of [ethyl-
14
C]NCI172112. Renal clearance of radioactivity is similar 4 h after administration of [
14
C]NCI172112 to rats with biliary cannulas, with 14.1±2.9 and 17.5±2.1% of the ethyl-
14
C and 34.5±2.5 and 33.1±6.3%, of the hydantoin-
14
C dose appearing in the urine after dosing with 3.13 and 6.25 mg/kg,
respectively. A difference in the 4 h urinary excretion of the two labels also is observed in dogs given [
14
C]NCI172112 (1 mg/kg, i.v.). The percentages of hydantoin-
14
C and ethyl-
14
C eliminated are 29.4±2.7% and 17.2±3.5%, respectively (P<0.05).
螺莫司汀
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-U00155 | 螺莫司汀 NCI172112 | 56605-16-4 | 1mg | 3000元 |
2024/08/19 | HY-U00155 | NCI172112 | | 5 mg | 8400元 |
56605-16-4, 螺莫司汀 相关搜索:
- 抑制剂
- 化合物 NCI172112
- 化合物 T12195
- 螺莫司汀
- 56605-16-4
- NCI172112,NCI-172112
- 1,3-Diazaspiro[4.5]decane-2,4-dione, 3-[2-[bis(2-chloroethyl)amino]ethyl]-
- NSC268497
- Spiromustine USP/EP/BP
- spirohydantoin mustard
- Spiromustine
- NCI172112
- 3-[2-[bis(2-chloroethyl)amino]ethyl]-1,3-diazaspiro[4.5]decane-2,4-quinone
- Spiromustard
- Spirohydantoin masturd
- SHM
- NSC-172112
- 3-[2-[Bis(2-chloroethyl)amino]ethyl]-1,3-diazaspiro[4.5]decane-2,4-dione