Sandramycin 是一种从 Nocardioides sp 的培养液中分离出来的一种环状十肽抗菌素。Sandramycin 也可以有效地结合 DNA，并且是一种 ADC 的毒素分子。Sandramycin 对革兰氏阳性细菌 (Gram-positive bacteria) 具有活性，并具有有效的抗肿瘤活性。
Sandramycin has antimicrobial activity wtih MIC values of 0.024 μg/mL, 0.012 μg/mL, 0.012 μg/mL, 0.098 μg/mL, 0.024 μg/mL, 12.5 μg/mL and 12.5 μg/mL for
Bacillus subtilis
(Rec
+
) A22508-2,
B. subtilis
(Rec
-
) A22509-2-2,
Staphylocccus aureus
209P-A9497,
S. aureus
(echinomycin-resistant) A9628,
Streptococcus faecalis
A96 1 1,
Escherichia coli
A151 19 and
E. coli
(actinomycin-sensitive) A21780 (AS-19), respectively.
Sandramycin inhibits cancer cells growth of L1210, B16, HCT118, RPMI8226, A431, RKO, SU-DHL6 and SU-DHL10 cells with IC
50
values of 0.02 nM, 0.07 nM, 0.8 nM, 3.8 nM, 3.1 nM, 1.3 nM, 5.9 nM and 3.3 nM, respectively.