氰胍佐旦
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- CAS号:
- 115344-47-3
- 英文名:
- SIGUAZODAN
- 英文别名:
- SKF 94836;SIGUAZODAN;SK AND F-94836;Siguazodan (SKF 94836);SKF-94836,inhibit,Phosphodiesterase (PDE),SKF94836,Siguazodan,Inhibitor;N-Cyano-Nmethyl-Nⅱ-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]guanidine;N-CYANO-N'-METHYL-N''-[4-(1,4,5,6-TETRAHYDRO-4-METHYL-6-OXO-3-PYRIDAZINYL)PHENYL]GUANIDINE;Guanidine, N-cyano-N'-methyl-N''-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]-;4β-Methyl-4,5-dihydro-3-[4-[[(cyanoimino)(methylamino)methyl]amino]phenyl]pyridazin-6(1H)-one;Siguazodan, N-Cyano-Nμ-methyl-N-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]guanidine
- 中文名:
- 氰胍佐旦
- 中文别名:
- 氰胍佐旦;化合物 T12913;化合物SIGUAZODAN
- CBNumber:
- CB6229034
- 分子式:
- C14H16N6O
- 分子量:
- 284.32
- MOL File:
- 115344-47-3.mol
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氰胍佐旦化学性质
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熔点:
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268-268.9 °C(lit.)
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密度:
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1.31±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: >5 mg/mL, freely soluble
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酸度系数(pKa):
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13.71±0.60(Predicted)
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形态:
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solid
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颜色:
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white
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氰胍佐旦性质、用途与生产工艺
Siguazodan (SKF 94836) 是一种有效的，选择性的，口服活性的磷酸二酯酶 III (PDE-III) 抑制剂，IC50 为 117 nM。Siguazodan 可增加完整血小板中 cAMP 的积累，EC50 为 18.88 μM。Siguazodan 还抑制苯肾上腺素诱导的 5-HT 释放，IC50 值为 4.2 μM。
IC50: 117 nM (phosphodiesterase III)
Siguazodan selectively inhibits the major cyclic AMP-hydrolysing PDE in human platelet supernatants. The inhibited enzyme has been variously termed cyclic GMP-inhibited PDE or PDE-III. In platelet-rich plasma (PRP), Siguazodan inhibits U46619-induced aggregation more potently than that induced by adenosine 5'-diphosphate (ADP), and collagen. Treatment of the PRP with Aspirin has no effect on the potency of Siguazodan. In washed platelets, Siguazodan increases cyclic AMP levels and reduces cytoplasmic free calcium. ADP decreases the ability of Siguazodan to raise cyclic AMP and this may explain its lower potency in inhibiting responses to ADP. Siguazodan has anti-platelet actions over the same concentration range that it is an inotrope and vasodilator.
Siguazodan is a potent, selective inhibitor of phosphodiesterase III that has positive inotropic and vasodilating actions in various laboratory animals and is orally active with a long duration of action in conscious dogs.
氰胍佐旦
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | HY-19026 | 氰胍佐旦
Siguazodan | 115344-47-3 | 5mg | 1000元 |
| 2024/11/08 | HY-19026 | Siguazodan | | 10 mM * 1 mLin DMSO | 1100元 |
氰胍佐旦
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氰胍佐旦国内生产厂家
115344-47-3, 氰胍佐旦 相关搜索:
- Cyclic Nucleotide related
- 抑制剂
- Cyclic Nucleotide Metabolism
- Phosphodiesterase Inhibitors
- G Proteins and Cyclic Nucleotides
- BioChemical
- Cell Signaling and Neuroscience
- Cell Biology
- C14H16N6O
- 化合物SIGUAZODAN
- 化合物 T12913
- 氰胍佐旦
- 115344-47-3
- SKF-94836,inhibit,Phosphodiesterase (PDE),SKF94836,Siguazodan,Inhibitor
- Guanidine, N-cyano-N'-methyl-N''-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]-
- 4β-Methyl-4,5-dihydro-3-[4-[[(cyanoimino)(methylamino)methyl]amino]phenyl]pyridazin-6(1H)-one
- [4S,(+)]-4,5-Dihydro-3-[4-[[(cyanoimino)(methylamino)methyl]amino]phenyl]-4-methylpyridazin-6(1H)-one
- [4R,(-)]-4,5-Dihydro-3-[4-[[(cyanoimino)(methylamino)methyl]amino]phenyl]-4-methylpyridazin-6(1H)-one
- Siguazodan (SKF 94836)
- Siguazodan, N-Cyano-Nμ-methyl-N-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]guanidine
- N-Cyano-Nmethyl-Nⅱ-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]guanidine
- N-CYANO-N'-METHYL-N''-[4-(1,4,5,6-TETRAHYDRO-4-METHYL-6-OXO-3-PYRIDAZINYL)PHENYL]GUANIDINE
- SKF 94836
- SK AND F-94836
- SIGUAZODAN